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1H-1-Ethyl Candesartan Cilexetil

1H-1-Ethyl Candesartan Cilexetil Structure
1H-1-Ethyl Candesartan Cilexetil
  • CAS No.914613-35-7
  • Chemical Name:1H-1-Ethyl Candesartan Cilexetil
  • CBNumber:CB42508599
  • Molecular Formula:C35H38N6O6
  • Formula Weight:638.71282
  • MOL File:914613-35-7.mol
1H-1-Ethyl Candesartan Cilexetil Property
  • Melting point 90-93°C
  • Boiling point 842.0±75.0 °C(Predicted)
  • Density 1.32
  • storage temp. Refrigerator
  • solubility ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide
  • form crystalline solid
  • pka 3.95±0.10(Predicted)
  • FDA UNII IN72J7R432
  • UNSPSC Code 41116107
  • NACRES NA.24
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements
  • Precautionary statements

1H-1-Ethyl Candesartan Cilexetil Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Uses Candesartan Cilexetil Impurity E (PHARMEUROPA).
  • Biological Activity 1h-1-ethyl candesartan cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin ii type 1 receptor (at1) antagonist.angiotensin ii is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including at1[1]. at1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. furthermore, at1 mediates the classical biological actions of angiotensin ii. also, at1 has seven helical transmembrane domains, which is the characteristic of the superfamily of g-protein-coupled receptors. carboxyl-terminal region structure of at1 plays important roles in receptor internalization, desensitization and phosphorylation [2].
  • References [1]. otsuka, m. reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin ii type 1 receptor antagonist. thorax. 2004; 59(1): 31-38.
    [2]. guo, d., sun, y., hamet, p., & inagami, t. the angiotensin ii type 1 receptor and receptor-associated proteins. cell research. 2001; 11(3): 165-180.
1H-1-Ethyl Candesartan Cilexetil Preparation Products And Raw materials
Raw materials
Preparation Products
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1H-1-Ethyl Candesartan Cilexetil Spectrum
914613-35-7, 1H-1-Ethyl Candesartan CilexetilRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Impurities
  • Heterocycles
  • Aromatics
  • 原料药
  • 抑制剂
  • 杂质对照品
  • 标准品
  • 294-坎地沙坦酯
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  • 坎地沙坦酯杂质5(坎地沙坦酯EP杂质E)
  • 坎地沙坦酯杂质05
  • 坎地沙坦酯杂质E/杂质V
  • 坎地沙坦 西里西替林 EP杂质E
  • CANDESARTAN CILEXETIL EP杂质 E
  • 坎地沙坦环丙基1位氮乙基杂质
  • 坎地沙坦酯杂质E(EP)
  • 1H-N1-乙基坎地沙坦酯
  • 坎地沙坦杂质 2
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  • 坎地沙坦酯EP杂质E
  • 914613-35-7
  • (1RS)-1-[[(Cyclohexyloxy)carbonyl]-oxy]ethyl 2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl
  • Candesartan Cilexetil Impurity 5(Candesartan Cilexetil EP Impurity E)
  • Candesartan EP Impurity-E
  • 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'- (1-ethyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)- 1H-benzo[d]imidazole-7-carboxylate
  • (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1- ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7- carboxylate
  • Candesartan Cilexetil,1H1ethyl Candesartan Cilexetil,Inhibitor,1H 1 ethyl Candesartan Cilexetil,inhibit
  • Candesartan Cilexetil impurity E
  • Candesartan Impurity 2
  • Candesartan Cilexetil Impurity 5(EP Impurity E)
  • Candesartan EP Imp E
  • 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(1-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
  • 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
  • Candesartan Cilexetil EP Impurity E (Candesartan Cilexetil N1-Ethyl Analog)
  • Candesartan Cilexetil EP Impurity EQ: What is Candesartan Cilexetil EP Impurity E Q: What is the CAS Number of Candesartan Cilexetil EP Impurity E Q: What is the storage condition of Candesartan Cilexetil EP Impurity E Q: What are the applications of Candesartan Cilexetil EP Impurity E
  • Candesartan Cilexetil EP IMpurity E
  • 2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-
  • 2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
  • 1H-1-Ethyl Candesartan Cilexetil

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