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2,4-Dichlorobenzyl alcohol

CAS No.1777-82-8
Chemical Name:2,4-Dichlorobenzyl alcohol
CBNumber:CB4156352
Molecular Formula:C7H6Cl2O
Formula Weight:177.03
MOL File:1777-82-8.mol

2,4-Dichlorobenzyl alcohol Property

Melting point 55-58 °C(lit.)
Boiling point 150 °C (25 mmHg)
Density 1.2970 (rough estimate)
vapor pressure 0.154Pa at 25℃
refractive index 1.5756 (estimate)
Flash point >230 °F
storage temp. 2-8°C
solubility 1g/l
pka 13.60±0.10(Predicted)
form Solid
color White to Off-White
Water Solubility Soluble in water, methanol and chloroform.
Merck 14,3060
BRN 1448652
InChIKey DBHODFSFBXJZNY-UHFFFAOYSA-N
LogP 2.8 at 24℃
CAS DataBase Reference 1777-82-8(CAS DataBase Reference)
FDA UNII 1NKX3648J9
EPA Substance Registry System 2,4-Dichlorobenzenemethanol (1777-82-8)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :24/25
WGK Germany :2
RTECS :DO0890000
Hazard Note :Irritant
HS Code :29062900
Toxicity :mouse,LD50,oral,2300mg/kg (2300mg/kg),Cosmetics and Toiletries. Vol. 95(6), Pg. 59, 1980.

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H318-H332-H412
Precautionary statements P261-P271-P273-P280-P304+P340+P312-P305+P351+P338

2,4-Dichlorobenzyl alcohol Price More Price(8)

Brand: Sigma-Aldrich(India)
Product number: 146668
Product name : 2,4-Dichlorobenzyl alcohol
Purity: 99%
Packaging: 50G
Price: ₹5997.05
Updated: 2022/06/14
Buy: Buy

Brand: ALFA India
Product number: ALF-A13338-36
Product name : 2,4-Dichlorobenzyl alcohol, 99%
Purity:
Packaging: 500g
Price: ₹18426
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-A13338-22
Product name : 2,4-Dichlorobenzyl alcohol, 99%
Purity:
Packaging: 100g
Price: ₹9759
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: D1837
Product name : 2,4-Dichlorobenzyl Alcohol
Purity: min. 97.0 %
Packaging: 25G
Price: ₹2700
Updated: 2022/05/26
Buy: Buy

Brand: ALFA India
Product number: ALF-A13338-14
Product name : 2,4-Dichlorobenzyl alcohol, 99%
Purity:
Packaging: 25g
Price: ₹2700
Updated: 2022/05/26
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2,4-Dichlorobenzyl alcohol Chemical Properties,Usage,Production

Chemical Properties white to light yellow crystal powde
Uses An surgical antiseptic.
Uses 2,4-Dichlorobenzyl alcohol is an antiseptic found in commercially available throat lozenges. Also used deactivate Respiratory syncytial virus and SARS-Cov.
Definition ChEBI: A member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines.
General Description 2,4-Dichlorobenzyl alcohol is a constituent of commercially available lozenges for acute sore throat caused by upper respiratory tract infections.
Mechanism of action In-vitro evidence has demonstrated the virucidal effect of Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) on a number of viruses associated with the common cold; a reduction in viral load is believed to have benefits in reducing the symptoms. The local anesthetic action of AMC/DCBA throat lozenges, a combination of the potent channel blocker – AMC and the reduced potency for sodium channel blockade DCBA – attenuate the effects of AMC, possibly as a result of competitive binding, which acts on a sodium channel blocker, and may be effective in relieving symptoms due to inflammation. Therefore, AMC/DCBA throat lozenge is thought to represent a useful option to meet patients' needs and avoid unnecessary prescription of antibiotics[1].
Clinical Use Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been marketed in many countries worldwide for pain relief in acute sore throat. Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been shown to be safe and efficient in relieving of acute sore throat symptoms, and it produces an immediate symptomatic relief. Local symptomatic pain relief plays an important role in managing acute sore throat[1-2].
Side effects COMMON SIDE EFFECTS: Difficulty in breathing, Tongue soreness, Hypersensitivity reactions, Swelling of the face, Tongue, Throat and Neck.
References [1] Ting W Tan. “Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol.” JBI database of systematic reviews and implementation reports (2017): 862–872.
[2] Thomas, Michael J. “ACP Journal Club. Amylmetacresol and 2, 4-dichlorobenzyl alcohol lozenges were better than placebo lozenges for relief of acute sore throat.” Annals of Internal Medicine 153 4 (2010): JC2-6.