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2-Iodophenol

CAS No.533-58-4
Chemical Name:2-Iodophenol
CBNumber:CB4130718
Molecular Formula:C6H5IO
Formula Weight:220.01
MOL File:533-58-4.mol

2-Iodophenol Property

Melting point 37-40 °C (lit.)
Boiling point 186-187 °C/160 mmHg (lit.)
Density 1.947 g/mL at 25 °C (lit.)
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Crystalline Powder or Crystalline Low Melting Mass
pka 8.51(at 25℃)
color White or cream to brown
Specific Gravity 1.947
Water Solubility slightly soluble
Sensitive Light Sensitive
Merck 14,5035
BRN 1855300
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey KQDJTBPASNJQFQ-UHFFFAOYSA-N
CAS DataBase Reference 533-58-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII F27L34A8B9
NIST Chemistry Reference Phenol, 2-iodo-(533-58-4)
EPA Substance Registry System Phenol, 2-iodo- (533-58-4)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xn,Xi
Risk Statements :20/21/22-36/37/38
Safety Statements :26-36-37/39
WGK Germany :3
RTECS :SL5500000
TSCA :T
HazardClass :IRRITANT, LIGHT SENSITIVE
HS Code :29081000

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302+H312+H332-H315-H319-H335
Precautionary statements P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338

2-Iodophenol Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: 281409
Product name : 2-Iodophenol
Purity: 98%
Packaging: 5G
Price: ₹1948.5
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 281409
Product name : 2-Iodophenol
Purity: 98%
Packaging: 25G
Price: ₹6516.65
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: I0460
Product name : 2-Iodophenol
Purity: min. 99.0 %
Packaging: 5G
Price: ₹3400
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-A13599-22
Product name : 2-Iodophenol, 98%
Purity:
Packaging: 100g
Price: ₹14713
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: I0460
Product name : 2-Iodophenol
Purity: min. 99.0 %
Packaging: 25G
Price: ₹7400
Updated: 2022/05/26
Buy: Buy

2-Iodophenol Chemical Properties,Usage,Production

Chemical Properties colorless needle-like crystals or Pale Yellow Low Melting Solid. Slightly soluble in water, easily soluble in organic solvents such as ethanol and ether.
Uses 2-Iodophenol is used in the synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity and 3,3-disubstituted-2,3-dihydrobenzofurans. Coupling with phenylacetylene in the presence of a Pd complex and CuI gives 2-phenylbenzofuran in good yield.
Definition ChEBI: 2-iodophenol is a 2-halophenol and an iodophenol.
Application 2-Iodophenol is a halophenol with antifungal activity. 2-Iodophenol was used in the synthesis of:
aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity
3,3-disubstituted-2,3-dihydrobenzofurans
1,3,5-substituted benzenes.
2-Iodophenol is also used as additive tracers for resist plasm a etching and suzuki reaction.
Preparation synthesis of 2-iodophenol: phenol (1a) to react with 0.5 equivalent of iodine and 1 equivalent of hydrogen peroxide in water at room temperature for 24 h, 2,6-diiodophenol (2a) and 2-iodophenol (3) were isolated in yields of 21 and 49%, respectively.
Synthesis Reference(s) The Journal of Organic Chemistry, 53, p. 5281, 1988 DOI: 10.1021/jo00257a014
General Description Rapid palladium-catalyzed carbonylative cyclization reactions of 2-iodophenol with various alkyne under microwave irradiation using Mo(CO)₆ as the CO source has been investigated.
Purification Methods Crystallise 2-iodophenol from CHCl3 or diethyl ether. The acetate has m 65-66o (from MeOH). [Beilstein 6 H 208, 6 II 198, 6 III 774, 6 IV 1074.]