ChemicalBook > CAS DataBase List > Argireline

Argireline

Description Application

Argireline

CAS No.616204-22-9
Chemical Name:Argireline
CBNumber:CB41092600
Molecular Formula:C34H60N14O12S
Formula Weight:889
MOL File:616204-22-9.mol

Argireline Property

Density 1.54
storage temp. -20°C
solubility water soluble
solubility water soluble
form lyophilized solid
pka 4.43±0.10(Predicted)
color white
Sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
InChIKey RJZNPROJTJSYLC-LLINQDLYSA-N
EWG's Food Scores 1
FDA UNII L4EL31FWIL
UNSPSC Code 12352200
NACRES NA.77

Safety

WGK Germany :2

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

Argireline Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: SML0395
Product name : Ac-EEMQRR-NH2 trifluoroacetate salt
Purity: ≥95% (HPLC)
Packaging: 1MG
Price: ₹37530.28
Updated: 2022/06/14
Buy: Buy

Argireline Chemical Properties,Usage,Production

Description
Argireline is made up of chains of amino acids. Such chains can affect how our cells work, e.g. relaxing our face muscles. It is derived from the peptide Acetyl hexapeptide-3, a substrate of Botulinum toxin, or more commonly known as Botox.
Application
Botox is a common, anti-wrinkle treatment which is applied using a needle. You may achieve the same anti-aging results with products which contain Argireline. Argireline can help prevent the formation of wrinkles by inhibiting muscle movement in the face. Because of this, Argireline cream is sometimes known as “Botox in a jar.”
Uses Argireline is an anti-wrinkle peptide. Synthetically produced and considered to be highly effective, clinical studies indicate it can reduce the depth of existing wrinkles. May be incorporated into products marketed as having a topical-BoToX. or “wrinkle-erasing” effect.
benefits Acetyl Hexapeptide-8 is effectivly reduce various kind of facial wrinkles;Replenish the collagen and polysaccharide, repairthe skin.Winkey patented productin China.It is recommended dosage is 3~10%.
Biological Activity Ac-EEMQRR-NH2 is a SNAP25 N-terminal-derived peptide th at inhibits the SNARE complex and possibly blocks neuronal exocytosis. Ac-EEMQRR-NH2 exhibits anti-inflammatory and anti-wrinkle activity. It is used as anti-wrinkle cosmetics ingredient.', 'Ac-EEMQRR-NH2 trifluoroacetate salt is considered 4000 times less toxic than botulin toxin. It has restricted transdermal penetration and hence has limited application for topical usage.
Clinical claims and research Argireline is a synthetic oligopeptide that emulates the sequence of SNAP-25, a type of SNARE. It has significant skin permeation, interferes with the SNARE ternary complex, and has demonstrated interference with catecholamine release from chromaffin cells. Topical use of 10% argireline resulted in a reduced depth and roughness of periorbital wrinkles in 10 healthy women. One study on 14 volunteers showed that 5% argireline reduced periorbital wrinkles by 32% in 28 days. Most recently, argireline’s efficacy has been measured in 60 Chinese women from a randomized control trial. Its total efficacy was 48.9% compared to 0% in the placebo group, and resulted in significantly decreased wrinkle roughness.