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2-Bromoethanol

Toxicity

2-Bromoethanol

CAS No.540-51-2
Chemical Name:2-Bromoethanol
CBNumber:CB3853766
Molecular Formula:C2H5BrO
Formula Weight:124.96
MOL File:540-51-2.mol

2-Bromoethanol Property

Melting point -80 °C
Boiling point 56-57 °C/20 mmHg (lit.)
Density 1.763 g/mL at 25 °C (lit.)
vapor density 4.3 (vs air)
vapor pressure 2.4 mm Hg ( 20 °C)
refractive index n20/D 1.492(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility 1-5 g/100 mL at 19°C
form Liquid
pka 13.82±0.10(Predicted)
color Clear colorless to yellow
Specific Gravity 1.7629 (20/4℃)
Water Solubility 1-5 g/100 mL at 19 ºC
Sensitive Light Sensitive
Merck 14,3792
BRN 878140
Stability Stable, but probably light sensitive. Hygroscopic. Incompatible with strong oxidizing agents. Flammable. Forms an azeotrope with water.
InChIKey LDLCZOVUSADOIV-UHFFFAOYSA-N
CAS DataBase Reference 540-51-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII Z33995S34R
NIST Chemistry Reference Ethanol, 2-bromo-(540-51-2)
EPA Substance Registry System 2-Bromoethanol (540-51-2)
UNSPSC Code 12352104
NACRES NA.22

Safety

Hazard Codes :T,T+,Xn,F
Risk Statements :23/24/25-34-40-36/37/38-26/27/28-10-67-65-48/20-38-11-63
Safety Statements :26-36/37/39-45-28A-16-62-36/37
RIDADR :UN 2922 8/PG 2
WGK Germany :3
RTECS :KJ8225000
TSCA :Yes
HazardClass :6.1
PackingGroup :II
HS Code :29055900

NFPA 704:

	0
4		1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H301+H311+H331-H314
Precautionary statements P280-P301+P310+P330-P301+P330+P331-P303+P361+P353-P304+P340+P311-P305+P351+P338

2-Bromoethanol Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: 48874
Product name : 2-Bromoethanol solution
Purity: certified reference material, 2000?μg/mL in toluene
Packaging: 1ML
Price: ₹4774.7
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: B0590
Product name : 2-Bromoethanol
Purity: min. 95.0 %
Packaging: 25G
Price: ₹2600
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: B0590
Product name : 2-Bromoethanol
Purity: min. 95.0 %
Packaging: 100G
Price: ₹4500
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: B0590
Product name : 2-Bromoethanol
Purity: min. 95.0 %
Packaging: 500G
Price: ₹21800
Updated: 2022/05/26
Buy: Buy

2-Bromoethanol Chemical Properties,Usage,Production

Toxicity 2-Bromoethanol can damage human body. The invasive ways of 2-bromoethanol include inhalation, ingestion and percutaneous absorption. 2-Bromoethanol has strong irritation to mucosa, upper respiratory tract, eyes and skin. Inhalation of 2-bromoethanol can cause death due to spasm, inflammation and edema of larynx and bronchus, chemical pneumonia and pulmonary edema. The manifestations of 2-bromoethanol poisoning include burning sensation, cough, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting.
Description 2-bromoethanol, a halogenated alipathic hydrocarbon, is a widely used industrial chemical. It is also a contaminant in food such as wheat and flour during treatment with ethylene oxide. 2-Bromoethanol was also found as a metabolite of 1,2-dibromoethane. A known carcinogen in experimental animals. 2-Bromoethanol is highly toxic in vivo and is a potent mutagen. Fatty acid conjugates of 2-bromoethanol that have been identified after 2-bromoethanol administration to rats may explain the long term 2-bromoethanol accumulation and retention in body tissues. Chronic exposure to 2-bromoethanol causes liver and kidney toxicity. 2- Bromoethanol also induces extensive lipid peroxidation in rat liver, kidney and testis slices and inhibits liver mitochondria respiration[1].
Chemical Properties colourless liquid
Chemical Properties 2-Bromoethanol is a colorless or light yellow hygroscopic liquid with relatively stable and toxic chemical properties. It plays a role in industrial and chemical experiments. It shall be stored in a ventilated, low-temperature and dry warehouse and separated from oxidants, acids and food additives. It is miscible with water and forms an azeotrope with water. The boiling point is 99.1 ℃ (101.35kpa). The aqueous solution has a sweet burning taste. It can be miscible with most organic solvents such as ethanol and ether, but insoluble in petroleum ether. The hydrolysis of aqueous solution can be accelerated when it meets acid, alkali and heating.
Uses 2-Bromoethanol is used in selective reduction of nitroarenes (PcFe(II)/NaBH4/2-bromoethanol catalyst system). It is not used much forany commercial purpose. The risk of exposure to this compound arises when ethylene oxide reacts with hydrobromic acid. It is used as a solvent and organic synthetic raw material. 2-Bromoethanol finds application in the synthesis of 2-piperidin-1-yl-ethanol by reacting with piperidine.
General Description Colorless to dark brown liquid. Sweet burning taste.
Air & Water Reactions Hygroscopic. Water soluble.
Reactivity Profile 2-Bromoethanol forms an azeotrope with water; hydrolysis of aqueous solutions is accelerated by heat, alkalis and acids.
Hazard Irritant to eyes and mucous membranes.
Health Hazard The vapors of ethylene bromohydrin are anirritant to the eyes and mucous membranes.It is corrosive to the skin. Ingestion of thiscompound can produce moderate to severetoxic effects. The target organs are the CNS,gastrointestinal tract, and liver. The lethaldose in mice by the intraperitoneal route was80 mg/kg.
Ethylene bromohydrin manifested car cinogenicity in test animals. It caused tumorsin lungs and the gastrointestinal tract in micefrom intraperitoneal (150 mg/kg/8 weeks)and oral (43 mg/kg/80 weeks) dosages,respectively. It is a mutagen, positive to thehistidine reversion–Ames test.
Fire Hazard 2-Bromoethanol is combustible.
Safety Profile Poison by intraperitoneal route. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Br-. See also
Synthesis Ethylene gas is washed and passed into an ice-cold solution of 7.2 g of bromine in 500 ml water. After complete absorption of the bromine, a fresh portion of 7.2 g, equal to the first, is added, with frequent and vigorous agitation, until a total weight of 200 g of bromine has reacted. The lower layer of ethylene dibromide, formed during the process, is separated, washed with water, and dried over sodium sulfate. Yield, 88 g. After neutralizing with the sodium carbonate and saturating the aqueous layer with sodium chloride, the 2-bromoethanol is extracted by shaking twice with 100 ml of ether, dried over sodium sulfate; the ether is removed by evaporation yielding 85 g of bulk of the residual liquid, which distils between 145-149° C. 54.4% of the bromine is converted into 2-bromoethanol and 37.5% into ethylene dibromide. The remainder is found as hydrobromic acid.
Waste Disposal Ethylene bromohydrin is mixed with a combustible solvent and burned in a chemicalincinerator.
References [1] Sumsullah Khan, Peter J. O’Brien, Christian Sood. “The Involvement of Cytochrome P4502E1 in 2-Bromoethanol-Induced Hepatocyte Cytotoxicity.” Basic Clinical Pharmacology Toxicology 78 4 (1996): 241–248.
[2] L. Jenneskens, J. Ripoll, U. Wiersum. “Flash vacuum thermolysis of 2-bromoethanol. Formation of α-bromoethylethers via 1-bromoethanol.” Tetrahedron Letters 62 1 (1988): 6489–6491.
[3] L. Homanen, J. Murto. “Infrared-induced rotamerization of 2-bromoethanol and 2-iodoethanol in argon matrices.” Chemical Physics Letters 85 1 (1982): 322–324.