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2-Amino-6-methylpyridine

CAS No.1824-81-3
Chemical Name:2-Amino-6-methylpyridine
CBNumber:CB3853241
Molecular Formula:C6H8N2
Formula Weight:108.14
MOL File:1824-81-3.mol

2-Amino-6-methylpyridine Property

Melting point 40-44 °C(lit.)
Boiling point 208-209 °C(lit.)
Density 1.0275 (estimate)
refractive index 1.5560 (estimate)
Flash point 218 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form Crystalline Low Melting Solid
pka pK1: 7.41(+1) (25°C)
color Yellow
Water Solubility very faint turbidity
Sensitive Hygroscopic
BRN 107048
InChIKey QUXLCYFNVNNRBE-UHFFFAOYSA-N
CAS DataBase Reference 1824-81-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 35ANN6MRBM
NIST Chemistry Reference 2-Pyridinamine, 6-methyl-(1824-81-3)
EPA Substance Registry System 2-Pyridinamine, 6-methyl- (1824-81-3)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :T
Risk Statements :25-36/37/38-24/25-23/24/25-24
Safety Statements :26-36/37/39-45-37/39-28A
RIDADR :UN 2811 6.1/PG 3
WGK Germany :3
RTECS :US1885000
F :10-21
TSCA :Yes
HazardClass :6.1
PackingGroup :II
HS Code :29333999

NFPA 704:

	1
4		1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H301-H310-H315-H319-H335
Precautionary statements P262-P280-P301+P310+P330-P302+P352+P310-P305+P351+P338

2-Amino-6-methylpyridine Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: A75706
Product name : 2-Amino-6-methylpyridine
Purity: 98%
Packaging: 100G
Price: ₹4286.7
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: A75706
Product name : 2-Amino-6-methylpyridine
Purity: 98%
Packaging: 500G
Price: ₹10987.38
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A0403
Product name : 2-Amino-6-methylpyridine
Purity: min. 98.0 %
Packaging: 25G
Price: ₹1700
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A0403
Product name : 2-Amino-6-methylpyridine
Purity: min. 98.0 %
Packaging: 100G
Price: ₹3400
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A0403
Product name : 2-Amino-6-methylpyridine
Purity: min. 98.0 %
Packaging: 500G
Price: ₹8900
Updated: 2022/05/26
Buy: Buy

2-Amino-6-methylpyridine Chemical Properties,Usage,Production

Chemical Properties YELLOWISH CRYSTALLINE LOW MELTING SOLID
Uses 2-Amino-6-methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Ka).
Uses Intermediate.
Definition 2-amino-6-methylpyridine, a colorless organic crystalline solid, is a prominent candidate to be exploited for the manufacturing of valuable compounds with biological activity. This synthetic nucleus can be used as precursor for the construction of diversified valuable scaffolds, e.g., 5-methyl-2-phenyl-3H-imidazo[4,5-b]pyridine and 6?bromo-5-methyl-2-phenylthiazolo[4,5-b]pyridine. The nitration of this nucleus in the presence of H2SO4 can yield N-(6-methyl-5-nitropyridin-2-yl)nitramide. It is also an important precursor for the generation of N-linked aminopiperidine-based gyrase inhibitors where during the course of reactions bromination of this nucleus was performed. Importantly, the amino group can be replaced by different halogen atoms, i.e. F, Cl, Br, or even by a nitroso group. Additionally, the methyl group on an aromatic system can be modified to the routine functional groups like aldehyde and carboxylic acid, or even bromination can be performed on this particular carbon[1].
Application 2-Amino-6-methylpyridine (2A6MPy) can be used as an electron donor and reacts with the π-acceptors tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 2,4,4,6-tetrabromo-2,5-cyclohexanediene dione (TBCHD) to form a solid charge transfer molecule in chloroform at 25 ℃. complex (CT), and the chemical formulae of the solid CT complexes were [(2A6MPy)(TCNE)2], [(2A6MPy)2(DDQ)], [(2A6MPy)4(TBCHD)], respectively^[2].
Purification Methods Crystallise it three times from acetone and dry it under vacuum at ca 45o. Alternatively, keep it in contact with NaOH pellets for 3hours, with occasional shaking, decant and fractionally distil it [Mod et al. J Phys Chem 60 1651 1956]. It also recrystallises from CH2Cl2 on addition of pet ether. [Marzilli et al. J Am Chem Soc 108 4830 1986, Beilstein 22/9 V 210.]
References [1] Ali A, et al. 2-Amino-6-methylpyridine based co-crystal salt formation using succinic acid: Single-crystal analysis and computational exploration. Journal of Molecular Structure, 2021; 1230: 129893.
[2] SHERZOD MADRAHIMOV . Electronic, infrared, mass spectrometry and thermal studies on the reaction of 2-amino-6-methylpyridine with π-acceptors[J]. Journal of Molecular Structure, 2020. DOI:10.1016/j.molstruc.2019.127021.