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Tripeptide-1

CAS No.72957-37-0
Chemical Name:Tripeptide-1
CBNumber:CB3702341
Molecular Formula:C16H28N6O6
Formula Weight:400.44
MOL File:72957-37-0.mol

Tripeptide-1 Property

storage temp. -20°C
form powder
color white
biological source synthetic (organic)
Water Solubility H2O: soluble 0.5mg/mL, clear, colorless
Sequence Gly-His-Lys
InChIKey MGNUTAFMLGJBGV-ACMTZBLWSA-N
SMILES C(=O)(O)C.[C@@H](NC(=O)CN)(C(=O)N[C@H](C(=O)O)CCCCN)CC1N=CNC=1 |&1:4,13,r|
CAS DataBase Reference 72957-37-0(CAS DataBase Reference)
FDA UNII 8AA809EUS9
UNSPSC Code 51111800
NACRES NA.77

Safety

WGK Germany :3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Hazard statements
Precautionary statements

Tripeptide-1 Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: G1887
Product name : Gly-His-Lys acetate salt
Purity: ≥97% (TLC)
Packaging: 10MG
Price: ₹16399.88
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: G7387
Product name : Gly-His-Lys acetate salt
Purity: BioXtra, γ-irradiated, suitable for cell culture
Packaging: 0.5MG
Price: ₹17320
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: G1887
Product name : Gly-His-Lys acetate salt
Purity: ≥97% (TLC)
Packaging: 50MG
Price: ₹58108.6
Updated: 2022/06/14
Buy: Buy

Brand: SRL
Product number: 47055
Product name : Glycine-L-Histidine-L-Lysine extrapure, 98%
Purity:
Packaging: 100mg
Price: ₹12210
Updated: 2022/05/26
Buy: Buy

Tripeptide-1 Chemical Properties,Usage,Production

Description Tripeptide-1 is a small peptide composed of three amino acids (glycine-histidine-lysine or GHK) and is known for type I collagen fragments. When collagen fragment peptides (GHK) are added, it may mistakenly lead the skin to think that collagen has been broken down, resulting in more collagen. Therefore, tripeptide-1 is believed to stimulate collagen production in the skin. More collagen will reduce wrinkles on the face, which will improve the condition of the skin.
Chemical Properties White powder
Uses Liver Cell Growth Factor
Uses Gly-His-Lys acetate salt has been used:
- individually or as a complex with copper to test its effect on cytokines production in the human normal fibroblasts cell lines
- as a model peptide in N,N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl)ammonium betaine based capillary electrophoresis separation studies
- as a component of Coon′s modified Ham′s F-12 medium for culturing Fischer rat thyroid follicular cell line, FRTL-5
General Description Gly-His-Lys is a tripeptide present at ～200ng/ml in association with α-globulin and albumin, in human blood plasma.
Biochem/physiol Actions Gly-His-Lys (GHK) acetate salt displays affinity towards copper(II) ions. This property enables GHK to modulate the copper intake into cells. GHK is also involved in quenching toxic by-products generated by lipid peroxidation.
in vitro In an enzyme assay, the liver growth factor, Tripeptide-1, was hydrolyzed by an aminotripeptidase purified from rat brain cytosol[1].
in vivo Tripeptide-1 (1% in saline; dose = 10 mg/kg) was injected into the tail vein of male rats (number not specified). Blood samples were collected prior to dosing and for up to 60 minutes post-dosing. Plasma concentration-time profiles of Tripeptide-1 and its l-histidyl-l-lysine metabolite indicated that neither was detected in predose plasma samples. However, after intravenous (IV) injection, Tripeptide-1 was rapidly degraded to l histidyl-l-lysine, rapidly eliminated from circulating blood. It has been reported that Tripeptide-1 is unstable in human plasma and is rapidly degraded by aminopeptidases[1].
References [1] Wilbur Johnson. “Safety Assessment of Tripeptide-1, Hexapeptide-12, Their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics.” International Journal of Toxicology 37 1 (2018): 102S–90S.