ChemicalBook > CAS DataBase List > TINZAPARIN SODIUM

TINZAPARIN SODIUM

TINZAPARIN SODIUM Property

solubility Dissolve 1.0 g in 10 mL of water R. The solution is clear (2.2.1) and not more intensely coloured than intensity 5 of the range of reference solutions of the most appropriate colour (2.2.2, Method II)
NCI Dictionary of Cancer Terms tinzaparin sodium
FDA UNII 3S182ET3UA
NCI Drug Dictionary tinzaparin sodium

Hazard and Precautionary Statements (GHS)

TINZAPARIN SODIUM Chemical Properties,Usage,Production

Uses Innohep (Pharmion).
Clinical Use
Peri- and postoperative surgical thromboprophylaxis
Treatment of DVT and pulmonary embolism
Prevention of thrombus formation in extracorporeal circulation during HD
Drug interactions Potentially hazardous interactions with other drugs
Analgesics: increased risk of bleeding with NSAIDs - avoid concomitant use with IV diclofenac; increased risk of haemorrhage with ketorolac - avoid concomitant use.
Nitrates: anticoagulant effect reduced by infusions of glyceryl trinitrate.
Use with care in patients receiving oral anticoagulants, platelet aggregation inhibitors, aspirin or dextran.
Metabolism Low molecular weight heparins are partially metabolised by desulphation and depolymerisation. The kidneys are the major site of tinzaparin excretion (approximately 70
% based on animal studies).