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MK-8353

MK-8353 Structure
MK-8353
  • CAS No.1184173-73-6
  • Chemical Name:MK-8353
  • CBNumber:CB34668195
  • Molecular Formula:C37H41N9O3S
  • Formula Weight:691.84
  • MOL File:1184173-73-6.mol
MK-8353 Property
  • Density 1.36±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility Soluble in DMSO
  • pka 11.89±0.40(Predicted)
  • form Solid
  • color Off-white to light brown
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

MK-8353 Chemical Properties,Usage,Production

  • Uses MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.
  • Definition ChEBI: MK-8353 is a member of the class of indazoles that is 1H-indazole substituted by a 6-(propan-2-yloxy)pyridin-3-yl group at position 3 and by a {[(3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)pyrrolidin-3-yl]carbonyl}amino group at position 5. It is a potent and selective inhibitor of ERK1 and ERK2 in vitro (IC50 values of 23.0 nM and 8.8 nM, respectively). The drug is being developed by Merck Sharp & Dohme and is currently in clinical development for the treatment of advanced/metastatic solid tumors. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of indazoles, a member of triazoles, a dihydropyridine, a member of pyridines, an aromatic ether, a secondary carboxamide, a pyrrolidinecarboxamide, a N-alkylpyrrolidine, a methyl sulfide and a tertiary carboxamide.
  • in vivo

    MK-8353 (60 mg/kg, p.o., bid (twice daily)) causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells, including LOX, Colo-205, MIA PaCa-2, and Calu-6 cells[1].

  • IC 50 ERK2: 8.8 nM (IC50); ERK1: 23 nM (IC50)
  • References [1] Moschos SJ, et al. Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors. JCI Insight. 2018 Feb 22;3(4). pii: 92352. DOI:10.1172/jci.insight.92352
MK-8353 Preparation Products And Raw materials
Raw materials
Preparation Products
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MK-8353 Spectrum
1184173-73-6, MK-8353Related Search:
  • 合成材料中间体
  • 合成有机化合物配体
  • 抑制剂
  • C37H41N9O3S
  • 化合物MK-8353,10 MM DMSO 溶液
  • (S)-N-(3-(6-异丙氧基吡啶-3-基)-1H-吲唑-5-基)-1-(2-(4-(4-(1-甲基-1H-1,2,4-三唑-3-基)苯基)-5,6-二氢吡啶-1(2H)- 基)-2-氧代乙基)-3-(甲硫基)吡咯烷-3-甲酰胺
  • 化合物MK-8353
  • 化合物 T12069
  • (3S)-1-[2-[3,6-二氢-4-[4-(1-甲基-1H-1,2,4-三唑-3-基)苯基]-1(2H)-吡啶基]-2-氧代乙基]-N-[3-[6-(1-甲基乙氧基)-3-吡啶基]-1H-吲唑-5-基]-3-(甲硫基)-3-吡咯烷甲酰胺
  • 1184173-73-6
  • MK-8353, 10 mM in DMSO
  • SCH900353 (MK-8353)
  • (S)-N-(3-(6-Isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide
  • SCH 900353,Extracellular signal regulated kinases,Inhibitor,inhibit,MK 8353,SCH-900353,MK-8353,ERK,MK8353
  • 3-Pyrrolidinecarboxamide, 1-[2-[3,6-dihydro-4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-1(2H)-pyridinyl]-2-oxoethyl]-N-[3-[6-(1-methylethoxy)-3-pyridinyl]-1H-indazol-5-yl]-3-(methylthio)-, (3S)-
  • MK-8353 (SCH900353)
  • SCH900353
  • SCH-900565
  • MK-8353

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