Application
3-Bromoacetanilide can be used as a pharmaceutical synthesis intermediate and an organic synthesis intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
Synthesis
Preparation of 3-bromoacetanilide: a 50 mL reaction vial was taken and 3-bromoacetophenone oxime (0.21 g, 1 mmol) dissolved in 2 mL of acetonitrile was transferred into the reaction vial and under stirring conditions, bismuth trifluoromethanesulfonate (0.10 g, 0.15 mmol) dissolved in 1 mL of acetonitrile was added and finally 2-3 mL of acetonitrile was added, and the reaction was carried out with stirring under an oil bath at 80 C. 3-bromoacetophenone oxime and bismuth trifluoromethanesulfonate were mixed and stirred, the solution immediately showed a slightly white suspension, and the reaction was monitored by TLC (DCM: 100%) until the reaction was complete, which was carried out for about 4 hours. The heating was stopped and the solvent was spun dry using a rotary evaporator, after which water and DCM were added to extract, the organic phases were combined and dried over anhydrous Na2SO4. Filtered, concentrated, separated by column chromatography (DCM: 100%), spun dry, evacuated, weighed the dried product 3-bromoacetanilide and calculated the yield to be 60%. mp86-88 C.
