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Thiazolyl Blue

Thiazolyl Blue Structure
Thiazolyl Blue
  • CAS No.298-93-1
  • Chemical Name:Thiazolyl Blue
  • CBNumber:CB3383104
  • Molecular Formula:C18H16BrN5S
  • Formula Weight:414.32
  • MOL File:298-93-1.mol
Thiazolyl Blue Property
  • Melting point 195 °C (dec.) (lit.)
  • Density 1.4886 (estimate)
  • storage temp. 2-8°C
  • solubility methanol: 5 mg/mL, clear
  • form powder
  • color Yellow to orange
  • Water Solubility Slightly soluble.Clear yellow solution at 5mg in 1ml of water on vortexing
  • λmax 378 nm, 242 nm
  • Sensitive Light Sensitive
  • BRN 3825277
  • Stability Hygroscopic
  • Biological Applications Cell viability assay; microbial growth assays; DNA quantification assays; tissue viability assays; detecting enzymes; measuring membrane potential; treating Alzheimer’s disease,asthma,cancer
  • InChIKey AZKSAVLVSZKNRD-UHFFFAOYSA-M
  • CAS DataBase Reference 298-93-1(CAS DataBase Reference)
  • EWG's Food Scores 1
  • FDA UNII EUY85H477I
  • EPA Substance Registry System 2H-Tetrazolium, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-, bromide (298-93-1)
  • UNSPSC Code 12352207
  • NACRES NA.75
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335-H341
  • Precautionary statements P201-P202-P261-P302+P352-P305+P351+P338-P308+P313
Thiazolyl Blue Price More Price(31)
  • Brand: Sigma-Aldrich(India)
  • Product number: M5655
  • Product name : Thiazolyl Blue Tetrazolium Bromide
  • Purity: powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97.5% (HPLC)
  • Packaging: 100MG
  • Price: ₹4872.9
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M5655
  • Product name : Thiazolyl Blue Tetrazolium Bromide
  • Purity: powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97.5% (HPLC)
  • Packaging: 500MG
  • Price: ₹11277.6
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M5655
  • Product name : Thiazolyl Blue Tetrazolium Bromide
  • Purity: powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97.5% (HPLC)
  • Packaging: 1G
  • Price: ₹18725.7
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M2128
  • Product name : Thiazolyl Blue Tetrazolium Bromide
  • Purity: 98%
  • Packaging: 100MG
  • Price: ₹3663
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M2128
  • Product name : Thiazolyl Blue Tetrazolium Bromide
  • Purity: 98%
  • Packaging: 250MG
  • Price: ₹5672.1
  • Updated: 2022/06/14
  • Buy: Buy

Thiazolyl Blue Chemical Properties,Usage,Production

  • Chemical Properties Thiazolyl Blue Tetrazolium Blue (MTT) is a water soluble tetrazolium salt yielding a yellowish solution when prepared in media or salt solutions lacking phenol red. Dissolved MTT is converted to an insoluble purple formazan by cleavage of the tetrazolium ring by dehydrogenase enzymes. This water insoluble formazan can be solubilized using isopropanol or other solvents and the dissolved material is measured spectrophotometrically yielding absorbance as a function of concentration of converted dye.
  • Uses Thiazolyl Blue Tetrazolium Blue (MTT) may be used in measurement of cell proliferation. MTT produces a yellowish solution that is converted to dark blue, water-insoluble MTT formazan by mitochondrial dehydrogenases of living cells. The blue crystals are solubilized with acidified isopropanol and the intensity is measured colorimetrically at 570 nm. MTT has been used as a histochemical/cytochemical reagent and for the detection of NAD. ADP-linked enzyme systems in tissue cannot be detected with MTT, due to binding of the cation by the cyanide trap used. MTT is rapidly reduced to the formazan, which chelates with nickel, copper, and cobalt; the cobalt chelate has been used in oxidative systems.
  • Definition ChEBI: Thiazolyl Blue is the bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium. It has a role as a dye and a colorimetric reagent. It contains a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.
  • General Description Thiazolyl Blue (MTT, Tetrazolium bromide, Methylthiazolyldiphenyl-tetrazolium bromide, Methylthialazole Tetrazolium) is a cell-permeable and positively charged colorimetric agent that is widely used to detect reductive metabolism in cells and to measure cell proliferation, cytotoxicity, and apoptosis. It is used as a direct indicator of cytotoxicity (such as for screening cancer drugs) and apoptosis. Thiazolyl Blue (MTT) is reduced from yellow color to purple formazan in living cells. As an electron acceptor, it is utilized for studying nicotinamide adenine dinucleotide phosphate (NADP)-dependent dehydrogenases.
  • Biochem/physiol Actions Cell permeable: yes
  • storage +4°C
  • Purification Methods It is recrystallised by dissolving in MeOH containing a few drops of HBr and then adding dry Et2O to complete the crystallisation, wash the needles with Et2O and dry them in a vacuum desiccator over KOH. [Beyer & Pyl Chem Ber 87 1505 1954, Beilstein 27 III/IV 6045.]
Thiazolyl Blue Preparation Products And Raw materials
Raw materials
Preparation Products
Thiazolyl Blue Suppliers
Global(421)Suppliers
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Thiazolyl Blue Spectrum
298-93-1, Thiazolyl BlueRelated Search:
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  • BioChemical
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  • C18H18BrN5S
  • C18H16BrN5S
  • C18H16N5SBr
  • 噻唑蓝,10 MM DMSO 溶液
  • THIAZOLYL BLUE TETRAZOLIUM BROMIDE (MTT),膜-PERMEABLE DYE
  • 噻唑四唑蓝溴化盐,噻唑蓝
  • 噻唑蓝染料
  • MTT 噻唑蓝 AMRESCO
  • 噻唑蓝/3-(4,5-二甲基-2-噻唑)-2,5-二苯基溴化四氮唑噻唑蓝/噻唑兰/溴化噻唑蓝四氮唑/3-(4,5-二甲基-2-噻唑基)-2,5-二苯基-2H-四氮唑/MTT
  • 2-(4,5-二甲基-2-噻唑基)-3,5-二苯基-2H-四唑-3-鎓盐溴化物
  • 噻唑蓝/3-(4,5-二甲基-2-噻唑)-2,5-二苯基溴化四氮唑噻唑蓝/噻唑兰/溴化噻唑蓝四氮唑/3-(4,5-二甲基-2-噻唑基)-2,5-二苯基-2H-四氮唑鎓溴化物/2-(4,5-二甲基-2-噻唑基)-3,5-二苯基-2H-四唑氢溴酸盐/MTT
  • 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基-2,3-二氢-1H-四唑-3-溴化物
  • 噻唑四唑蓝溴化盐
  • 噻唑兰
  • 3-(4,5-二甲基-2-噻唑基)-2,5-二苯基-2H-四氮唑鎓溴化物
  • 噻唑兰 MTT

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