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2-Pyridinecarbothioamide, N-2-pyridinyl-

2-Pyridinecarbothioamide, N-2-pyridinyl- Structure
2-Pyridinecarbothioamide, N-2-pyridinyl-
  • CAS No.39122-38-8
  • Chemical Name:2-Pyridinecarbothioamide, N-2-pyridinyl-
  • CBNumber:CB33207720
  • Molecular Formula:C11H9N3S
  • Formula Weight:215.27
  • MOL File:39122-38-8.mol
2-Pyridinecarbothioamide, N-2-pyridinyl- Property
  • Melting point 82 °C(Solv: ethanol, 70% (64-17-5))
  • Boiling point 378.2±40.0 °C(Predicted)
  • Density 1.323±0.06 g/cm3(Predicted)
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2.5 mg/ml
  • form A crystalline solid
  • pka 8.76±0.70(Predicted)
  • color Light yellow to yellow
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

2-Pyridinecarbothioamide, N-2-pyridinyl- Chemical Properties,Usage,Production

  • Uses NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1].
  • in vivo

    NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1].

  • References [1] Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8. DOI:10.1016/j.ccell.2017.11.005
2-Pyridinecarbothioamide, N-2-pyridinyl- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Pyridinecarbothioamide, N-2-pyridinyl- Suppliers
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2-Pyridinecarbothioamide, N-2-pyridinyl- Spectrum
39122-38-8, 2-Pyridinecarbothioamide, N-2-pyridinyl-Related Search:
  • 抑制剂
  • 药靶配体
  • 化合物NSC 185058
  • N-(吡啶-2-基)吡啶-2-硫代甲酰胺
  • 39122-38-8
  • Inhibitor,NSC-185058,Atg4,NSC 185058,Autophagy,Autophagy-related 4,inhibit
  • N-(Pyridin-2-yl)pyridine-2-carbothioamide
  • NSC 185058
  • 2-Pyridinecarbothioamide, N-2-pyridinyl-

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