5-Amino-1-methylpyrazole-4-carboxamide

Synthesis

5334-41-8

18213-75-7

The general procedure for the synthesis of 5-amino-1-methyl-1H-pyrazole-4-carboxamide from 1-methyl-4-cyano-5-amino-1,2-pyrazole was carried out as follows: a mixture of 1-methyl-4-cyano-5-amino-1,2-pyrazole (0.11 mol) and concentrated sulfuric acid (30 mL, 0.6 mol) was stirred for 1 h at room temperature. Upon completion of the reaction, the mixture was slowly poured into ice water and the pH was adjusted to 8 with 50% aqueous ammonium hydroxide under ice bath conditions.Subsequently, the precipitated solid product was filtered and washed with cold water to give the final 5-amino-1-methyl-1H-pyrazole-4-carboxamide (13.5 g, 91% yield).

References