ChemicalBook > CAS DataBase List > Norethandrolone
Norethandrolone
Norethandrolone
- CAS No.52-78-8
- Chemical Name:Norethandrolone
- CBNumber:CB3146312
- Molecular Formula:C20H30O2
- Formula Weight:302.45
- MOL File:52-78-8.mol
Norethandrolone Property
- Melting point 130-136°C
- Boiling point 383.47°C (rough estimate)
- Density 1.0434 (rough estimate)
- refractive index 1.4980 (estimate)
- storage temp. -20°C
- solubility Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
- form A crystalline solid
- pka 15.13±0.40(Predicted)
- CAS DataBase Reference 52-78-8(CAS DataBase Reference)
- FDA UNII P7W01638W6
- ATC code A14AA09
- NIST Chemistry Reference Norethandrolone(52-78-8)
Safety
- Hazard Codes :F,T
- Risk Statements :60-61-11-19-38
- Safety Statements :53-45
-
Symbol(GHS)
- Signal wordWarning
- Hazard statements H373-H361-H351-H362
- Precautionary statements P201-P260-P263-P264-P270-P308+P313-P260-P314-P501-P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501
Norethandrolone Chemical Properties,Usage,Production
- Chemical Properties mp 130-136oC
- Originator Nilevar,Searle,US,1956
- Uses Controlled substance (anabolic steroid). Androgen.
- Uses Norethandrolone is antinauseant and antiemetic highly specific and selective serotonin subtype 3 (5-HT3) receptor antagonist
- Definition ChEBI: Norethandrolone is a corticosteroid hormone.
- Manufacturing Process Through a mixture of 11 parts of charcoal containing 5% palladium and 2,000 parts of dioxane a stream of hydrogen is passed for 60 minutes. Then 86 parts of 17-ethynyl-19-nortestosterone (Norethindrone) in 1,500 parts of dioxane are added and the mixture is hydrogenated until 2 mols of hydrogen are absorbed. The catalyst is then removed by filtration and the solvent is evaporated under vacuum. The crystalline residue is dissolved in 2,700 parts of benzene and thus applied to a chromatography column containing 5,000 parts of silica gel. The column is washed with 2,700 parts of benzene, 4,500 parts of a 10% solution of ethyl acetate in benzene and 27,000 parts of a 20% solution of ethyl acetate in benzene and is then eluted with 30,000 parts of a 30% solution of ethyl acetate in benzene. The resulting eluate is concentrated under vacuum and the residue is recrystallized from methanol and dried to constant weight at 75°C. The 17-ethyl-19-nortestosterone thus obtained melts at about 140°C to 141°C.
- Therapeutic Function Androgen
Norethandrolone Preparation Products And Raw materials
Raw materials
Preparation Products
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52-78-8, NorethandroloneRelated Search:
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- 17-alpha-Ethyl-17-hydroxy-4-norandrosten-3-one
- 17-alpha-Ethyl-17-hydroxy-19-norandrost-4-en-3-one
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- Norethandrolone solution
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