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Isoquinoline, 5-iodo- (9CI)

Isoquinoline, 5-iodo- (9CI) Structure
Isoquinoline, 5-iodo- (9CI)
  • CAS No.58142-99-7
  • Chemical Name:Isoquinoline, 5-iodo- (9CI)
  • CBNumber:CB31053800
  • Molecular Formula:C9H6IN
  • Formula Weight:255.06
  • MOL File:58142-99-7.mol
Isoquinoline, 5-iodo- (9CI) Property
  • Boiling point 336.8±15.0 °C(Predicted)
  • Density 1.837±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C(protect from light)
  • solubility Ethanol:25.51(Max Conc. mg/mL);100.0(Max Conc. mM)
    DMSO:25.51(Max Conc. mg/mL);100.0(Max Conc. mM)
  • form solid
  • pka 4.48±0.13(Predicted)
  • color Yellow to brown
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • HS Code  :2933491090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H319-H335-H302+H312+H332-H315
  • Precautionary statements P280-P301+P312-P362+P364

Isoquinoline, 5-iodo- (9CI) Chemical Properties,Usage,Production

  • Uses DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1].
  • Biological Activity DSRM-3716 is a potent and selective SARM1 NADase inhibitor (NAD+ hydrolysis IC50 = 75 nM using recombinant SARM1 SAM-TIR construct) th at recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy (EC50 = 2.1/1.9 μM by fragmentation/NfL release using mouse DRG neurons; 81/88% protection by 1/3 μM DSRM-3716 using human iPSC-derived motor neurons) or mitochondrial dysfunction (3-30 μM DSRM-3716 against 25 μM rotenone-induced injury; mouse DRG neurons). Mechanistically, DSRM-3716 undergoes base exchange with the nicotinamide (NAM) moiety of nicotinamide adenine dinucleotide (NAD+) to yield the bona fide inhibitor 1AD.
  • storage Store at -20°C
  • References [1] Robert O Hughes, et al. Small Molecule SARM1 Inhibitors Recapitulate the SARM1 -/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Cell Rep. 2021 Jan 5;34(1):108588. DOI:10.1016/j.celrep.2020.108588
Isoquinoline, 5-iodo- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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Isoquinoline, 5-iodo- (9CI) Spectrum
58142-99-7, Isoquinoline, 5-iodo- (9CI)Related Search:
  • ISOQUINOLINE
  • 抑制剂
  • 高端化学
  • 菲啰啉 喹啉 异喹啉
  • 化工原料
  • 5-碘异喹啉,10 MM DMSO 溶液
  • 5-碘异喹啉
  • 58142-99-7
  • DSRM-3716, 10 mM in DMSO
  • DSRM3716,SARM1,DSRM-3716,NADase,neurodegenerative,cADPR,Inhibitor,5-Iodoisoquinoline,DSRM 3716,axon,inhibit
  • DSRM-3716 (Synonyms: 5-Iodoisoquinoline)
  • Isoquinoline, 5-iodo-
  • Isoquinoline, 5-iodo- (9CI)

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