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Nicotinamide riboside malate

Nicotinamide riboside malate Structure
Nicotinamide riboside malate
  • CAS No.2415659-01-5
  • Chemical Name:Nicotinamide riboside malate
  • CBNumber:CB29272941
  • Molecular Formula:
  • Formula Weight:0
  • MOL File:Mol file
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
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Nicotinamide riboside malate Chemical Properties,Usage,Production

  • Uses Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].
  • in vivo

    Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1].

    Animal Model:10-week-old C57Bl/6J mice[1]
    Dosage:400 mg/kg
    Administration:PO; daily; for 16 weeks
    Result:Increased plasma and intracellular NAD+ content in a tissue-specific manner.
  • IC 50 SIRT1; SIRT3; Human Endogenous Metabolite
  • References [1] Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. DOI:10.1016/j.cmet.2012.04.022
    [2] Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. DOI:10.1016/j.neurobiolaging.2012.12.005
    [3] Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480. DOI:10.1101/2020.04.17.047480
Nicotinamide riboside malate Preparation Products And Raw materials
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Nicotinamide riboside malate Spectrum
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