Terallethrin

Description

Terallethrin is particularly effective when used as thermal fumigation to control mosquitoes, and its knockdown activity against housefly and Culex pipiens is higher than that of allethrin and natural pyrethrins.

Chemical Properties

The industrial product is a light yellow oily liquid with a vapor pressure of 2.7×10-2Pa (20℃), insoluble in water and soluble in various organic solvents. It is unstable under sunlight and easily decomposed in alkali. Toxicity: The acute oral LD50 of rats is 174-224 mg/kg.

Uses

Terallethrin is particularly effective when used as thermal fumigation to control mosquitoes, and its knockdown activity against housefly and Culex pipiens is higher than that of allethrin and natural pyrethrins. The knockdown activity against German cockroach is also better than that of allethrin.

Production Methods

Terallethrin was produced through a sequence typical of early allethrin type esters. Industrial manufacture began with preparation of the chrysanthemic acid (or chrysanthemate) acid chloride intermediate, generated from the corresponding acid under controlled chlorination conditions. In parallel, the required alcohol component, derived from substituted tetrahydrofurfuryl or related allylic alcohols, was synthesised and purified. These two fragments were then coupled via esterification in an anhydrous, base scavenged environment to form terallethrin, after which the crude product was refined by distillation or crystallisation to reach technical grade purity for formulation.

Mechanism of action

Neurotoxin, disturbs the function of neurons by interaction with the sodium channel.

Pesticide Type

Insecticide