Tucotuzumab Celmoleukin
- Product NameTucotuzumab Celmoleukin
- CAS339986-90-2
- CBNumberCB28080785
- MW0
- MOL FileMol file
Chemical Properties
| form | Liquid |
| color | Colorless to light yellow |
Tucotuzumab Celmoleukin Chemical Properties,Usage,Production
Uses
Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule[1].in vivo
Tucotuzumab (75 μg; intratumoral injection; 5 daily of 15 μg (total dose of 75 μg), each in 50 μL PBS; on days 10 and 14) results in significantly greater tumor growth suppression and enhances survival[1].
| Animal Model: | Female Balb/c mice bearing CT26-KS colon adenocarcinoma[1] |
| Dosage: | 75 μg |
| Administration: | Intratumoral injection; 5 daily of 15 μg (total dose of 75 μg), each in 50 μL PBS; on days 10 and 14 |
| Result: | Resulted in significantly greater tumor growth suppression and enhanced survival. |
References
[1] Erik E Johnson, et al. Radiofrequency ablation combined with KS-IL2 immunocytokine (EMD 273066) results in an enhanced antitumor effect against murine colon adenocarcinoma. Clin Cancer Res. 2009 Aug 1;15(15):4875-84. DOI:10.1158/1078-0432.CCR-09-0110Tucotuzumab Celmoleukin Suppliers
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