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4-Chlorobenzyl alcohol

Description Referrence

CAS No.873-76-7
Chemical Name:4-Chlorobenzyl alcohol
CBNumber:CB2714497
Molecular Formula:C7H7ClO
Formula Weight:142.58
MOL File:873-76-7.mol

4-Chlorobenzyl alcohol Property

Melting point 68-71 °C(lit.)
Boiling point 234 °C(lit.)
Density 1.1104 (rough estimate)
refractive index 1.5390 (estimate)
Flash point 70 °C
storage temp. Sealed in dry,Room Temperature
solubility 2.5g/l
pka 14.16±0.10(Predicted)
form Crystalline Needles or Powder
color Almost white to beige
Water Solubility Soluble in water (2.5 mg/ml at 20°C), and methanol.
BRN 636502
Stability Stable. Incompatible with acid chlorides, acid anhydrides, acids, oxidizing agents. Combustible.
CAS DataBase Reference 873-76-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII GF8BS53B6V
NIST Chemistry Reference 4-Chlorobenzyl alcohol(873-76-7)
EPA Substance Registry System 4-Chlorobenzenemethanol (873-76-7)
UNSPSC Code 77101502
NACRES NA.22

Safety

Safety Statements :22-24/25
WGK Germany :3
RTECS :DN9242000
HS Code :29062900

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P305+P351+P338

4-Chlorobenzyl alcohol Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: C27115
Product name : 4-Chlorobenzyl alcohol
Purity: 99%
Packaging: 25G
Price: ₹7458.43
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: C27115
Product name : 4-Chlorobenzyl alcohol
Purity: 99%
Packaging: 100G
Price: ₹13704.45
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: C0565
Product name : 4-Chlorobenzyl Alcohol
Purity: min. 99.0 %
Packaging: 25G
Price: ₹7200
Updated: 2022/05/26
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Brand: ottokemi
Product number: C 2021
Product name : 4-Chloro benzyl alcohol+
Purity: 98%
Packaging: 25gm
Price: ₹4509
Updated: 2022/05/26
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Brand: ottokemi
Product number: C 2021
Product name : 4-Chloro benzyl alcohol+
Purity: 98%
Packaging: 100gm
Price: ₹12069
Updated: 2022/05/26
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4-Chlorobenzyl alcohol Chemical Properties,Usage,Production

Description It is usually used as the intermediate in organic synthesis and pharmaceutical industry. Specifically, this chemical can react with o-xylene in the presence of HAuCl4 or AuCl3 at 80 ℃ to generate the corresponding benzylated product.¹ Moreover, the acetylation of 4-chlorobenzyl alcohol in presence of catalytic amounts of Ce(OTf)4 has been performed in acetic acid to produce the desired esters in the excellent yields.² In addition, this chemical may function as the raw material to produce its corresponding carboxylic acids and ketones in good yields through the oxidation reaction by using hydrogen peroxide and cobalt(Ⅱ) complex.³ Besides, the formylation and acetylation of 4-chlorobenzyl alcohol may be carried out in the presence of Silphos [PCl3?n(SiO2)n] in ethyl formate and ethyl acetate.⁴
Referrence
1. Mertins, K.; Lovel, I.; Kischel, J.; Zapf, A.; Beller, M., Gold-catallyzed benzylation of arenes and heteroarenes. Adv. Synth. Catal. 2006, 348, 691-695.
2. Iranpoor, N.; Shekarriz, M., Catalytic Esterification of Alcohols, Carboxylic Acids and Transesterification Reactions with Cerium(IV) Triflate. Bull. Chem. Soc. Jpn. 1999, 72, 455-458.
3. Das, S.; Punniyamurthy, T., Cobalt(II)-catalyzed oxidation of alcohols into carboxylic acids and ketones with hydrogen peroxide. Tetrahedron Lett. 2003, 44, 6033-6035.
4. Iranpoor, N.; Firouzabadi, H.; Jamalian, A., Silphos PCl3-n(SiO2)(n) : a heterogeneous phosphine reagent for formylation and acetylation of alcohols and amines with ethyl formate and acetate. Tetrahedron Lett. 2005, 46, 7963-7966.
Chemical Properties white crystalline powder
Uses Reagent for carboxyl group protection.
Uses 4-Chlorobenzyl alcohol acts as a reagent for the protection of carboxyl groups as their 4-chlorobenzyl esters, more stable to acid than the corresponding benzyl esters. It is used as solvent in paint stripper and waterborne coatings. It acts as curing agent. It is also used in pharmaceuticals, cosmetics, preservatives, and flavoring & fragrance agents.
Synthesis Reference(s) Journal of the American Chemical Society, 82, p. 681, 1960 DOI: 10.1021/ja01488a045