Hydroxyzine pamoate can be administered intravenously and orally[2].
Hydroxyzine pamoate metabolite deschlorocycline induces congenital malformations[4].
Example of configuring an oral suspension of Hydroxyzine pamoate 5 mg/mL: Hydroxyzine pamoate 850 mg, Xanthan gum 1 g, Propylene glycol 5 mL, Sorbic acid 200 mg, Sorbitol solution 20 mL, Flavor q.s., Syrup q.s. to 100 mL[5].
| Animal Model: | Mature female pregnant rats weighing 240 g[4] |
| Dosage: | 100, 200 mg/kg |
| Administration: | |
| Result: | Showed 100 mg/kg produced 25.7% and 42.9% deformed pups per kilogram of body weight; 200 mg/kg produced 100% deformed pups per kilogram of body weight. |
| Animal Model: | Dog received IV hydroxyzine dihydrochloride[2][3] |
| Dosage: | 2 mg/kg; daily; one day |
| Administration: | Intravenous injection (i.v.); Oral gavage (p.o.) |
| Result: | Showed that there was no significant difference at the 5% level in GWS (erythema×firmness×average diameter) between the two dosing methods. |
