Z-VDVAD-AFC (trifluoroacetate salt) Chemical Properties,Usage,Production
Description
Z-VDVAD-AFC is a fluorogenic substrate for caspase-2.1 Upon enzymatic cleavage by caspase-2, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify caspase-2 activity. AFC displays excitation/emission maxima of 400/505 nm, respectively.WARNING This product is not for human or veterinary use.
References
[1] LI JIA. Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis[J]. Oncogene, 2001, 20 35: 4817-4826. DOI: 10.1038/sj.onc.1204628
