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Sirt2-PROTAC-1

Sirt2-PROTAC-1 Structure
Sirt2-PROTAC-1
  • CAS No.2098487-75-1
  • Chemical Name:Sirt2-PROTAC-1
  • CBNumber:CB24668512
  • Molecular Formula:C40H40N10O8S2
  • Formula Weight:852.94
  • MOL File:2098487-75-1.mol
Sirt2-PROTAC-1 Property
  • Density 1.52±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO : ≥ 100 mg/mL (117.24 mM);Water : < 0.1 mg/mL (insoluble)
  • form Solid
  • pka 7.94±0.50(Predicted)
  • color White to off-white
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Sirt2-PROTAC-1 Chemical Properties,Usage,Production

  • Uses PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM)[1].
  • IC 50 SIRT2: 0.25 μM (IC50)
  • References [1] Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491. DOI:10.1021/acs.jmedchem.6b01872
Sirt2-PROTAC-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Sirt2-PROTAC-1 Suppliers
Global(21)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32265
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  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier： cjbscvictory
  • Tel：13348960310<br/>13348960310
  • Email：3003867561@qq.com
  • Country：China
  • ProdList：10523
  • Advantage：58
  • Supplier： InvivoChem
  • Tel： 13549236410
  • Email：sales@invivochem.cn
  • Country：China
  • ProdList：6753
  • Advantage：58
Sirt2-PROTAC-1 Spectrum
2098487-75-1, Sirt2-PROTAC-1Related Search:
  • C40H40N10O8S2
  • 2098487-75-1
  • N-{4-[4-({3-[(2-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamido}-1,3-thiazol-5-yl)methyl]phenoxy}methyl)-1H-1,2,3-triazol-1-yl]butyl}-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
  • PROTAC Sirt2 Degrader-1
  • Sirt2-PROTAC-1

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