Description
C6 D-
threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-
threo Ceramide is cytotoxic to U937 cells
in vitro (IC
50 = 18 μM). It is metabolically inactive and, unlike C6 L-
erythro ceramide , C6 D-
threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-
threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM. It enhances IL-4 production induced by phorbol 12-myristate 13-acetate (PMA; ) in EL4 T cells when used at a concentration of 10 μM. [Matreya, LLC. Catalog No. 1809]
References
[1] Park J, et al. Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells. Bioorg Med Chem. 2005 Apr 1;13(7):2589-95. DOI:
10.1016/j.bmc.2005.01.027[2] Irie F, et al. Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations. J Neurosci Res. 1998 Nov 15;54(4):475-85. DOI:
10.1002/(SICI)1097-4547(19981115)54:4<475::AID-JNR5>3.0.CO;2-P
