Synthesis
The general procedure for the synthesis of 4-(2-chlorophenyl)-1,3-thiazol-2-amine from o-chloroacetophenone and the compound (CAS:17356-08-0) was as follows: firstly, 2'-chloroacetophenone (0.05 mol), iodine (0.1 mol), and thiourea (0.1 mol) were mixed in a small conical flask and ground thoroughly using a mortar and pestle until homogeneous (reaction 1). Subsequently, the mixture was placed in a microwave reactor and radiated at 180 W power for 5 min, during which time it was paused every 30 sec. Upon completion of the reaction, 100 mL of distilled water was added to the mixture and microwave heating was continued at 270 W power for 5-6 min, with pauses at 1 min intervals to ensure complete dissolution of the precipitate. The reaction solution was cooled and filtered to obtain a yellow filtrate. The filtrate was adjusted to alkaline with ammonia solution to precipitate the target product. The product was separated by filtration, purified by recrystallization with ethanol and ether successively, and finally dried under reduced pressure to give 4-(2-chlorophenyl)-1,3-thiazol-2-amine.
References
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[3] Journal of Heterocyclic Chemistry, 2002, vol. 39, # 6, p. 1133 - 1138
[4] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 305 - 313
[5] Arzneimittel-Forschung/Drug Research, 1986, vol. 36, # 9, p. 1391 - 1393
