Uses
NAP is a neuroprotective peptide. It can also be used in biological study of integrating network, sequence and functional features using machine learning approaches towards identification of novel Alzheimer genes.
Definition
ChEBI: Davunetide is an oligopeptide.
Biological Activity
Davunetide (NAPVSIPQ; NAP) is an eight amino acid peptide identified as the active component of activity-dependent neuroprotective protein (ADNP). It has been found to be neuro-protective at femtomolar concentrations in vitro against the neural toxicity of a wide range of compounds. Davunetide has been investigated for Parkinsonμs disease and schizophrenia and in clinical trials for Alzheimnerμs Disease, targeting microtubule-tau Interaction.
in vivo
Davunetide (2 μg/kg; Intranasally; daily, 5 days a week, for 16 weeks) shows protective effects for central nervous system complications in a diabetes rat model[3].
| Animal Model: | Male Sprague-Dawley rats (Induced by an i.p. streptozotocin (STZ) injection)[3] |
| Dosage: | 2 μg/kg |
| Administration: | Intranasally beginning on the day following the STZ injection and were given daily, 5 days a week, for 16 weeks |
| Result: | Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. Davunetide treatment significantly improved both measurements.
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