ChemicalBook > CAS DataBase List > SAR-20347

SAR-20347

SAR-20347 Structure
SAR-20347
  • CAS No.1450881-55-6
  • Chemical Name:SAR-20347
  • CBNumber:CB23052811
  • Molecular Formula:C21H18ClFN4O4
  • Formula Weight:444.84
  • MOL File:1450881-55-6.mol
SAR-20347 Property
  • Boiling point 698.3±65.0 °C(Predicted)
  • Density 1.445±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO:94.5(Max Conc. mg/mL);212.43(Max Conc. mM)
  • form A solid
  • pka 13.97±0.50(Predicted)
  • color Light yellow to yellow
  • UNSPSC Code 12352200
  • NACRES NA.77
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
SAR-20347 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML2915
  • Product name : SAR-20347
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹11593.58
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML2915
  • Product name : SAR-20347
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹46677.4
  • Updated: 2022/06/14
  • Buy: Buy

SAR-20347 Chemical Properties,Usage,Production

  • Uses SAR-20347 is a small molecule inhibitor with specificity for JAK1 and tyrosine kinase 2 (TYK2).
  • Biochem/physiol Actions SAR-20347 is an orally active, ATP-competitive, TYK2- and JAK1-selective tyrosine kinase inhibitor (IC50 = 13 nM/TYK2 & 59 nM/JAK1 vs. 0.88 μM/JAK2 & 1.44 μM/JAK3 with 10 μM ATP) that effectively inhibits cellular TYK2- (IL12-induced pSTAT4 IC50 = 107 nM/CD4+ cells, 126 nM/NK-92) and JAK1- (IL6-induced pSTAT3 IC50 = 345 nM/TF-1, 407 nM/CD14+ cells) mediated signaling with little affinity toward 72 other kinases. SAR-20347 suppresses IL22-induced serum amyloid A (by 44%; 50 mg/kg p.o. 30 min prior to 10 μg IL22 i.p.) and alleviates imiquimod-induced psoriasis-like dermatitis (30 min prior and 5 h post daily 62.5 mg 5% imiquimod cream) in mice in vivo.
  • in vivo

    60 mg/kg SAR-20347 inhibits the production of IFN-γ in the serum by 91% compare to vehicle-treated animals, demonstrating that SAR-20347 can inhibit TYK2 signaling in vivo. SAR-20347 treatment significantly reduces IL-17 production as measured by average signal intensity, consistent with the gene expression analysis[1].

  • IC 50 Tyk2: 0.6 nM (IC50); JAK1: 23 nM (IC50); JAK2: 26 nM (IC50); JAK3: 41 nM (IC50)
SAR-20347 Preparation Products And Raw materials
Raw materials
Preparation Products
SAR-20347 Suppliers
Global(76)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38636
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：52924
  • Advantage：58
  • Supplier：
    Suzhou ARTK Medchem Co., Ltd.
  • Tel：+86-512-68323658<br/>+86-18168183658
  • Email：sales1@artkmedchem.com
  • Country：China
  • ProdList：39003
  • Advantage：58
SAR-20347 Spectrum
1450881-55-6, SAR-20347Related Search:
  • JAK1 & TYK2
  • 抑制剂
  • 标准品
  • 细胞生物学试剂
  • 1450881-50-6
  • 化合物SAR20347,10 MM DMSO 溶液
  • 2-(2-氯-6-氟苯基)-5-((4-(吗啉-4-羰基)苯基)氨基)恶唑-4-羧酰胺
  • 化合物SAR20347
  • TYK2/JAK1/JAK2和JAK3抑制剂(SAR-20347)
  • 1450881-55-6
  • SAR-20347, 10 mM in DMSO
  • inhibit,SAR 20347,Janus kinase,JAK,SAR-20347,Inhibitor
  • 4-Oxazolecarboxamide, 2-(2-chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-
  • SAR-20347;SAR 20347;SAR20347
  • CS-2527
  • 2-(2-chloro-6-fluorophenyl)-5-({4-[(morpholin-4-yl)carbonyl]phenyl}amino)-1,3-oxazole-4-carboxylic acid amide
  • 2-(2-chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide
  • CPDD1211
  • SAR-20347

Home

My