ChemicalBook > CAS DataBase List > AST-1306

AST-1306

AST-1306 Structure
AST-1306
  • CAS No.1050500-29-2
  • Chemical Name:AST-1306
  • CBNumber:CB22646572
  • Molecular Formula:C31H26ClFN4O5S
  • Formula Weight:621.0783432
  • MOL File:1050500-29-2.mol
AST-1306 Property
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO
  • form Powder
  • color Light yellow to yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

AST-1306 Chemical Properties,Usage,Production

  • Uses Alitinib (AST-1306) is a structural analog of lapatinib, a new quinazoline anti-tumor drug, and a small molecule epidermal growth factor receptor tyrosine kinase inhibitor, which selectively acts on EGFR/ErbB2 /ErbB4 receptor.
  • Biological Activity ast-1306 is a selective, irreversible inhibitor of erbb2 and egfr with ic50 values of 0.5nm and 3nm, respectively [1].ast-1306 is designed and synthesized based on the chemical structure of lapatinib. the molecular docking method shows ast-1306 binds to the atp-binding pocket of the kinases and form covalent bind with certain amino acids. ast-1306 can inhibit egfr and erbb2 in a cell-free assay with more than 3000-fold selectivity to other kinases. besides the wild-type egfr, ast-1306 also inhibits egfr mutant t790m/l858r both in a cell-free assay and in hih3t3 cells. the growth of the cells is suppressed by ast-1306 due to the inhibition of the phosphorylation of egfr. it also occurs in some human cancer cells. experiments have proved that ast-1306 notly inhibits the phosphorylation of egfr and erbb2 and subsequently decreases the downstream pathways of these kinases in a549 cells, calu-3 cells and sk-ov-3 cells. moreover, ast-1306 potently inhibits the tumor growth both in erbb2-overexpressing xenograft models and fvb-2/nneu transgenic mouse model [1].
  • in vivo

    AST1306 tosylate (AST-1306 (TsOH); p.o.; 25-100 mg/kg; twice daily; for 28 days) causes a dramatic suppression of tumor growth in SK-OV-3 and Calu-3 xenograft models[1].

    Animal Model:Nude mice with SK-OV-3 and Calu-3 tumors[1]
    Dosage:25, 50, 100 mg/kg
    Administration:p.o.; twice daily; for 28 days
    Result:Caused a dramatic suppression of tumor growth.
  • target ErbB2
  • IC 50 EGFR: 0.5 nM (IC50); ErbB2: 3 nM (IC50); EGFRL858R/T790M: 12 nM (IC50); ErbB4: 0.8 nM (IC50)
  • References [1] xie h, lin l, tong l, jiang y, zheng m, chen z, jiang x, zhang x, ren x, qu w, yang y, wan h, chen y, zuo j, jiang h, geng m, ding j. ast1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. plos one. 2011;6(7):e21487.
AST-1306 Preparation Products And Raw materials
Raw materials
Preparation Products
AST-1306 Suppliers
Global(96)Suppliers
  • Supplier：
    Biochempartner
  • Tel：0086-13720134139
  • Email：candy@biochempartner.com
  • Country：CHINA
  • ProdList：965
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32200
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38636
  • Advantage：58
  • Supplier：
    GIHI CHEMICALS CO.,LIMITED
  • Tel： +8618058761490
  • Email：info@gihichemicals.com
  • Country：China
  • ProdList：49984
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：57505
  • Advantage：58
AST-1306 Spectrum
1050500-29-2, AST-1306Related Search:
  • Anti-cancer&immunity
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • 药靶配体
  • 标准品
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 蛋白酪氨酸激酶
  • 抗肿瘤及免疫抑制剂
  • C31H26ClFN4O5S
  • C24H18ClFN4O2C7H8O3S
  • ALLITINIB TOSYLATE艾力替尼 |CAS 1050500-29-2
  • 艾力替尼,10 MM DMSO 溶液
  • N-(4-((3-氯-4-((3-氟苄基)氧基)苯基)氨基)喹唑啉-6-基)丙烯酰胺 4-甲基苯磺酸盐
  • 化合物AST-1306 TSOH
  • 极光A抑制剂I
  • 艾力替尼甲磺酸盐
  • EGFR和ERBB2抑制剂(AST-1306 TSOH)
  • 艾力替尼甲磺酸盐(AST1306)
  • 艾力替尼
  • N-[4-[[3-氯-4-[(3-氟苯基)甲氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯酰胺对甲苯磺酸盐
  • 1050500-29-2
  • Allitinib tosylate (AST-1306 TsOH, AST-6)
  • Allitinib tosylate, 10 mM in DMSO
  • N-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)acrylamide 4-methylbenzenesulfonate
  • Allitinib tosylate AST-1306
  • AST1306; AST 1306
  • CS-249
  • AST-130
  • AST-1306 USP/EP/BP
  • 2-Propenamide, N-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-, 4-methylbenzenesulfonate (1:1)
  • Allitinib tosylate
  • AST-1306 mesylate
  • AST 1306 tosylate
  • AST1306 tosilate
  • AST-1306 (TsOH)
  • AST1306 (p-Toluenesulfonic acid)
  • AST-1306 (p-Toluenesulfonic acid)
  • AST 1306 (p-Toluenesulfonic acid)
  • N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide 4-methylbenzenesulfonate
  • AST-6

Home

My