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AZ 628

AZ 628 Structure
AZ 628
  • CAS No.878739-06-1
  • Chemical Name:AZ 628
  • CBNumber:CB22516246
  • Molecular Formula:C27H25N5O2
  • Formula Weight:451.52
  • MOL File:878739-06-1.mol
AZ 628 Property
  • Density 1.21±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO: soluble10mg/mL, clear
  • form powder
  • pka 12.92±0.70(Predicted)
  • color white to beige
  • FDA UNII 560S6B5D79
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :T
  • Risk Statements  :25-36/37/38
  • Safety Statements  :26-36/37/39-45
  • RIDADR  :UN 2811 6.1 / PGIII
  • WGK Germany  :3
  • HS Code  :2922500090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H315-H319-H335
  • Precautionary statements P301+P310+P330-P302+P352-P305+P351+P338
AZ 628 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0785
  • Product name : AZ628
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹11799.3
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0785
  • Product name : AZ628
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹47552.4
  • Updated: 2022/06/14
  • Buy: Buy

AZ 628 Chemical Properties,Usage,Production

  • Uses AZ 628 is an inhibitor of B-RAF and B-RAF(V600E)
  • Definition ChEBI: 3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxo-6-quinazolinyl)amino]phenyl]benzamide is a member of benzamides.
  • Biological Activity az628 is a potent and newly discorvered inhibitor of braf, c-raf-1 and brafv600e with ic50 values of 105 nm, 29 nm and 34 nm, respectively. this compound prevents craf activation through persistently occupying the atp-binding site of raf kinase. specificity profile suggests that az628 also inhibits activation of other tyrosine protein kinases such as ddr2, vegfr2, lyn, flt1, fms and others.raf kinases a family of three serine/threonine-specific protein kinases and participate in the ras-raf-mek-erk signal transduction cascade, also known as the mitogen-activated protein kinase (mapk) cascade. the activation of mapk signaling leads to different cellular response such as cell proliferation, apoptosis and inflammation.az628 has the potent anti-tumor activity. in human colon and melanoma-derived cell line that carries the recurrent v600e activating braf mutation, az628 was shown to inhibit anchorage-dependent and -independent growth, induce cell cycle arrest, and cause apoptosis [1]. az628 may be antiangiogenic due to inhibition of vegfr2 [2].generation of melanoma cell line clones is obtained resistance to the raf kinase inhibitor az628. resistance to az628 is connected with raised levels of the raf downstream effector p-erk1/2. erk1/2 initiation in az628-resistant clones is interceded by mek. supported multiplication of az628-resistant clones is to a great extent autonomous of braf kinase action. az628-resistant clones express elevated craf. survival of az628-safe cells is subject to craf [1].
  • in vitro

    AZ628 inhibits B-Raf, B-Raf AZ628 acts on B-Raf-containing M14 parental cell lines treated with increasing concentrations of AZ628, an effective inhibition of p-ERK1/2 levels was observed. It acts on AZ628-resistant M14 cells and does not inhibit ERK activation. AZ628 acts on NRAS-mutated malignant melanoma cells and effectively reduces ERK activation.

  • target
    TargetValue
    C-Raf-1
    (Cell-free assay)    		 29 nM
    B-Raf (V600E)
    (Cell-free assay)    		 34 nM
    B-Raf
    (Cell-free assay)    		 105 nM
  • storage Store at +4°C
  • References 1. montagut c, sharma sv, shioda t, mcdermott u, ulman m, ulkus le, et al. elevated craf as a potential mechanism of acquired resistance to braf inhibition in melanoma. cancer res 2008,68:4853-4861.2. khazak v, astsaturov i, serebriiskii ig, golemis ea. selective raf inhibition in cancer therapy. expert opin ther targets 2007,11:1587-1609.
AZ 628 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ 628 Suppliers
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AZ 628 Spectrum
878739-06-1, AZ 628Related Search:
  • MAPK
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 合成有机化合物配体
  • 药靶配体
  • 抑制剂
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 化合物AZ 628,10 MM DMSO 溶液
  • 3-(2-氰基丙烷-2-基)-N-(4-甲基-3-((3-甲基-4-氧代-3,4-二氢喹唑啉-6-基)氨基)苯基)苯甲酰胺
  • AZ 628,适用于BRAF,BRAFV600E和C-RAF的新型PAN-RAF抑制剂
  • 化合物AZ 628
  • RAF抑制剂(AZ 628)
  • 3-(1-氰基-1-甲基乙基)-N-[3-[(3,4-二氢-3-甲基-4-氧代-6-喹唑啉基)氨基]-4-甲基苯基]苯甲酰胺
  • 878739-06-1
  • 3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide
  • AZ 628, 10 mM in DMSO
  • AZ 628,Raf,inhibit,Inhibitor,AZ-628,AZ628,Raf kinases,Apoptosis
  • az628 DISCONTINUED, duplicate of A807000
  • CS-70
  • cas 878739-06-1
  • AZ-628;CAS 878739-06-1;AZ 628;AZ628
  • 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)
  • Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-
  • 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)ben
  • AZ628, >=99%
  • 3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide
  • AZD628
  • AZ628/AZ-628
  • AZ-628
  • 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide

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