Description References
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Cinobufagin

Description References
Cinobufagin Structure
Cinobufagin
  • CAS No.470-37-1
  • Chemical Name:Cinobufagin
  • CBNumber:CB2206701
  • Molecular Formula:C26H34O6
  • Formula Weight:442.55
  • MOL File:470-37-1.mol
Cinobufagin Property
  • Melting point 133 °C(lit.)
  • Boiling point 300 °C(lit.)
  • Density 1.261 g/cm3
  • Flash point >230 °F
  • storage temp. 2-8°C
  • solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
  • form powder to crystal
  • pka 15.10±0.70(Predicted)
  • color White to Light yellow
  • FDA UNII T9PSN4R8IR
  • NCI Drug Dictionary cinobufagin
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300-H310-H330
  • Precautionary statements P260-P264-P280-P284-P302+P350-P310
Cinobufagin Price More Price(2)
  • Brand: TCI Chemicals (India)
  • Product number: C3460
  • Product name : Cinobufagine
  • Purity: 
  • Packaging: 25MG
  • Price: ₹6800
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: C3460
  • Product name : Cinobufagine
  • Purity: 
  • Packaging: 100MG
  • Price: ₹22500
  • Updated: 2022/05/26
  • Buy: Buy

Cinobufagin Chemical Properties,Usage,Production

  • Description Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, having similar effects to digitalis and used in traditional Chinese medicine. It has potential antineoplastic activity and now is widely used in clinical practice, especially in anti-liver cancer. It has benn found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators, including mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9.
  • References 1. https://en.wikipedia.org/wiki/Cinobufagin
    2. https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689412
    3. http://www.yourdictionary.com/cinobufagin
    4. https://www.medchemexpress.com/cinobufagin.html
  • Description Cinobufagin is a cardiotonic steroid that has been found in the skin of toads of genus Bufo and has diverse biological activities. It inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates by 45% when used at a concentration of 0.3 μM. Cinobufagin is cytotoxic to HCT116 colorectal cancer cells in vitro with IC50 values of less than 50 ng/ml at 48- and 72-hour time points and induces apoptosis in a concentration-dependent manner. In vivo, cinobufagin (10 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. Cinobufagin (1 μg/ml) inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells. It also increases expression of the antimicrobial peptides hBD2 and hBD3 in dendritic cells. Cinobufagin exhibits dose-dependent antinociceptive effects in the hot-plate, acetic acid writhing, and formalin tests in mice.
  • Uses Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
  • Definition ChEBI: Cinobufagin is a steroid lactone. It is functionally related to a bufanolide.
  • in vivo

    Cinobufagin (5 mg/kg for i.p., once a day for 10 days) inhibits xenograft growth by inducing cell apoptosis in tumor xenograft mice model[1].
    Cinobufagin (5 mg/kg for i.p., once a day for 10 days) suppresses tumor growth in both subcutaneous and intracranial U87MG-EGFR xenograft mouse models and increases the median survival of nude mice bearing intracranial U87MGEGFR tumors[2].

    Animal Model:OCM1 cells tumor xenograft in Nu/Nu nude mice [1]
    Dosage:5 mg/kg
    Administration:Intraperitoneal injection (i.p.), once a day for 10 days
    Result:Made the tumors grew more slowly than those treated with intraperitoneal injection of saline or untreated.
    Increased the expression of caspase-3 and PARP in tumor tissues and decreased Bcl-2 and Bcl-xl expression in mouse tumor tissues and increased expression of Bad and Bax.
    Animal Model:U87MG-EGFR subcutaneous and intracranial xenograft model[2]
    Dosage:5 mg/kg
    Administration:Intraperitoneal injection (i.p.), once a day for 10 days
    Result:Decreased the luminescence intensity of brain tumor about 70%.
    Decreased p-EGFR, p-STAT3, and p-Akt levels in the intracranial tumors as compared with the vehicles.
    Decreased Ki67 and active caspase-3 immunostaining of intracranial tumors.
Cinobufagin Preparation Products And Raw materials
Raw materials
Preparation Products
Cinobufagin Suppliers
Global(233)Suppliers
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  • Tel：+1-631-485-4226
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Cinobufagin Spectrum
470-37-1, CinobufaginRelated Search:
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  • Proteomics and Protein Expression
  • C26H34O6nH2O
  • C26H34O6
  • 华蟾蜍精,10 MM DMSO 溶液
  • 华蟾毒精/HPLC
  • (1R,2R,2AR,3AS,3BR,5AR,7S,9AS,9BS,11AR)-7-羟基-9A,11A-二甲基-1-(2-氧代-2H-吡喃-5-基)十六氢萘并[1',2':6,7]茚并[1,7A-B]环氧乙烷-2-基 乙酸酯
  • 标准品对照品】CINOBUFAGIN
  • 华蟾毒精(对照品)
  • 实验用华蟾毒精
  • 华蟾酥毒基华蟾毒精
  • 华蟾酥毒基对照品
  • 蟾酥CINOBUFAGIN
  • 华蟾蜍精、华蟾毒精、华蟾蜍毒基、华蟾毒配基
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  • 华蟾蜍精, 来源于蟾酥
  • 华蟾毒配基(华蟾毒精)
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  • 华蟾酥毒基
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  • 华蟾毒精/华蟾酥毒基
  • 华蟾毒精(配基)
  • 华蟾酥毒基(97%)

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