Synthesis
GENERAL METHODS: Aryl halides (1.0 mmol), morpholine (1 mmol), sodium tert-butoxide (2 mmol) and 0.2 mol% of Pd/Nf-G catalyst were sequentially added to 1 mL of dimethyl sulfoxide (DMSO). The reaction mixture was stirred at 110 °C for 12 h. The reaction process was monitored by gas chromatography (GC). Upon completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate. The catalyst was recovered by simple filtration and subsequently washed with ethanol, dried and stored for subsequent use. The crude product was purified by column chromatography with the eluent being a mixed petroleum ether/ethyl acetate solvent. The recovered catalyst was reused in subsequent recyclability studies. The conversion of the reactants was determined by gas chromatography (GC).
References
[1] Bulletin of the Chemical Society of Japan, 1991, vol. 64, # 1, p. 42 - 49
[2] Applied Organometallic Chemistry, 2013, vol. 27, # 12, p. 704 - 706
[3] RSC Advances, 2014, vol. 4, # 96, p. 53387 - 53396
[4] Tetrahedron Letters, 2015, vol. 56, # 30, p. 4463 - 4467
[5] Tetrahedron Letters, 2016, vol. 57, # 14, p. 1532 - 1536
