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kukoamine A

kukoamine A Structure
kukoamine A
  • CAS No.75288-96-9
  • Chemical Name:kukoamine A
  • CBNumber:CB21355400
  • Molecular Formula:C28H42N4O6
  • Formula Weight:530.66
  • MOL File:75288-96-9.mol
kukoamine A Property
  • Boiling point 872.1±65.0 °C(Predicted)
  • Density 1.213±0.06 g/cm3 (20 ºC 760 Torr)
  • storage temp. Store at -20°C
  • solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
  • form A crystalline solid
  • pka 9.48±0.10(Predicted)
  • color Off-white to yellow
  • CAS DataBase Reference 75288-96-9
  • FDA UNII 9YM64FBW2R
  • UNSPSC Code 41116107
  • NACRES NA.24
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

kukoamine A Chemical Properties,Usage,Production

  • Description Kukoamine A is a spermine alkaloid originally isolated from L. chinense that has diverse biological activities, including anticancer, neuroprotective, and anti-inflammatory properties. Kukoamine A (5-20 μg/ml) inhibits colony formation of U251 and WJ1 glioblastoma cells in a concentration-dependent manner. It halts the cell cycle at the G0/G1 phase and induces apoptosis when used at concentrations of 60 and 80 μg/ml. Kukoamine A (20 and 40 μM) induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury. It increases the number of dopamine neurons in the substantia nigra and striatum, decreases α-synuclein expression, and improves motor function in an MPTP mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg per day. Kukoamine A (10 and 20 mg/kg) decreases IL-1β, TNF-α, and COX-2 protein levels in the hippocampus and increases hippocampal neurogenesis in a rat model of radiation injury. It also selectively inhibits trypanothione reductase (Ki = 1.8 μM), an enzyme that protects certain parasites from oxidative stress, over human glutathione reductase (Ki = >10 mM).
  • Occurrence The root bark of Lychium chinense yields this alkaloid. Kukoamine A possesses hypotensive activity inducing hypotension in rats at a dose of 5 mg/kg when given intravenously.
  • Uses Kukoamine A is a neuroprotective agent which is used to prevent the loss of dopaminergic neurons in substantia nigra.
  • Definition ChEBI: Kukoamine A is an amine.
  • IC 50 Trypanosoma
kukoamine A Preparation Products And Raw materials
Raw materials
Preparation Products
kukoamine A Suppliers
Global(111)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
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  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    Aktin Chemicals, Inc.
  • Tel：028-85159085
  • Email：info@aktinchem.com
  • Country：CHINA
  • ProdList：1025
  • Advantage：58
kukoamine A Spectrum
75288-96-9, kukoamine ARelated Search:
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  • 地骨皮甲素,10 MM DMSO 溶液
  • 地骨皮甲素/生物碱类(ALKALOIDS)
  • 库克敏A
  • 地骨皮甲素对照品
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  • 库库胺A
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  • 苦可胺A、柯碱A
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  • 苦可胺 A
  • 地骨皮甲素(苦可胺 A)
  • 地骨皮甲素
  • 75288-96-9
  • Kukoamine A, 10 mM in DMSO
  • NSC-5398
  • NSC5398
  • NSC 5398
  • N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide)
  • Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-
  • N1,N12-Bis(dihydrocaffeoyl) spermine
  • N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide]
  • N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide]
  • 1,14-Bis(dihydrocaffeoyl)spermidine
  • kukoamine A

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