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Azlocillin sodium

Azlocillin sodium Structure
Azlocillin sodium
  • CAS No.37091-65-9
  • Chemical Name:Azlocillin sodium
  • CBNumber:CB2128131
  • Molecular Formula:C20H22N5NaO6S
  • Formula Weight:483.47
  • MOL File:37091-65-9.mol
Azlocillin sodium Property
  • Melting point >199oC (dec.)
  • Flash point >110°(230°F)
  • storage temp. Inert atmosphere,2-8°C
  • solubility H2O: soluble50mg/mL
  • form powder
  • color White to Off-White
  • Water Solubility Freely soluble in water
  • Stability Hygroscopic
  • CAS DataBase Reference 37091-65-9(CAS DataBase Reference)
  • FDA UNII DWV1EFW947
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :42/43
  • Safety Statements  :36
  • WGK Germany  :3
  • RTECS  :XH9250000
  • Toxicity :mouse,LD50,intramuscular,15420mg/kg (15420mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: TREMORBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX),Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. Vol. 32, Pg. 453, 1987.
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H317-H334
  • Precautionary statements P280-P302+P352
Azlocillin sodium Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: A7926
  • Product name : Azlocillin sodium salt
  • Purity: 
  • Packaging: 1G
  • Price: ₹11907.5
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: A7926
  • Product name : Azlocillin sodium salt
  • Purity: 
  • Packaging: 5G
  • Price: ₹29779.58
  • Updated: 2022/06/14
  • Buy: Buy

Azlocillin sodium Chemical Properties,Usage,Production

  • Originator Securopen,Bayer,W. Germany,1977
  • Uses Antibacterial;Bacterial transpeptidase inhibitor
  • Uses Azlocillin sodium is a semisynthetic penicillin and is a potent 1-lactam antibiotic. It is often used against Pseudomonas aeruginosa and has been used to develop novel antibiotic quantitation techniques.
  • Definition ChEBI: Azlocillin sodium is an organic sodium salt. It contains an azlocillin(1-).
  • Manufacturing Process 3.8 parts by weight of D-(-)-α-[(imidazolidin-2-on-1-yl)carbonylamino]phenylacetic acid were dissolved in 65 parts by volume of dichloromethane. 2.7 parts by weight of 1-methyl-2-chloro-δ1-pyrrolinium chloride were added, and after cooling to -10°C 2.0 parts by volume of triethylamine were added gradually. This reaction mixture was then stirred for one hour at -5°C (mixture A). 4.0 parts by weight of 6-aminopenicillanic acid in 80 parts by volume of dichloromethane were treated with 4.4 parts by volume of triethylamine and 4.0 parts by weight of anhydrous sodium sulfate and then stirred for two hours at room temperature. After filtration, the solution was cooled to -20°C and combined with the mixture A. The reaction mixture was left to reach 0°C of its own accord, and was then stirred for a further hour at 0°C. The solvent was removed in a rotary evaporator, the residue was dissolved in water, and the solution was covered with a layer of ethyl acetate and acidified with dilute hydrochloric acid at 0° to 5°C, while stirring, until pH 1.5 was reached. The organic phase was then separated off, washed with water, dried over magnesium sulfate while cooling, and filtered, and after dilution with an equal amount of ether the sodium salt of the penicillin was precipitated from the filtrate by adding a solution of sodium 2-ethylcaproate dissolved in ether containing methanol. Yield: 1.3 parts by weight.
  • brand name Azlin (Bayer).
  • Therapeutic Function Antibacterial
Azlocillin sodium Preparation Products And Raw materials
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Azlocillin sodium Spectrum
37091-65-9, Azlocillin sodiumRelated Search:
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