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Norgestimate

Norgestimate Structure
Norgestimate
  • CAS No.35189-28-7
  • Chemical Name:Norgestimate
  • CBNumber:CB2110884
  • Molecular Formula:C23H31NO3
  • Formula Weight:369.5
  • MOL File:35189-28-7.mol
Norgestimate Property
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H361fd
  • Precautionary statements P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313
Norgestimate Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR2119
  • Product name : Norgestimate
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 500MG
  • Price: ₹21812.38
  • Updated: 2022/06/14
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  • Brand: Sigma-Aldrich(India)
  • Product number: 94497
  • Product name : Norgestimate
  • Purity: analytical standard
  • Packaging: 50MG
  • Price: ₹9038.88
  • Updated: 2022/06/14
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Norgestimate Chemical Properties,Usage,Production

  • Description Norgestimate is an orally-effective progestogen, recently launched in combination with ethinyl estradiol as an oral contraceptive.
  • Chemical Properties White Crystalline Solid
  • Originator Ortho (USA)
  • Uses Progestogen. In combination with estrogen as oral contraceptive.
  • Uses antifungal
  • Definition ChEBI: Norgestimate is a steroid ester, a ketoxime and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive.
  • Manufacturing Process A solution of 4.5 g of D-17β-acetoxy-13β-ethyl-17α-ethynyl-gon-4-en-3-one in 15 ml of pyridine and 2.0 g of hydroxylamine hydrochloride hydroxylamine hydrochloride is heated on a steam bath for 45 min. It is then cooled and poured into a large amount of ice-water, after which the solid which is thus produced is filtered off and air dried. Recrystallization from methylene chloride-ethanol gives D-17β-acetoxy-13α-ethyl-17α-ethynyl-gon-4-en-one oxime, m.p. 214-218°C; [α]D25 = +41°.
  • brand name CILEST
  • Therapeutic Function Progestin
  • General Description Norgestimate, (17α)-17-acetyloxy-13-ethyl-18,19-dinor-pregn-4-en-20yn-3-one oxime, is a 19-nortestosterone, 3-oxime prodrug that is orally active andused with an estrogen in oral contraceptive products. It hasminimal androgenic action. Norgestimate is metabolized to17-deacetylnorgestimate (norelgestromin) and norgestrel,which provide the progestational action.
  • in vitro norgestimate was found that, unlike other 19-nortestosterone derivatives, showed high selectivity for the progesterone receptor and low androgenic activity. moreover, norgestimate and its main active metabolite norelgestromin could not bind to or occupy sex hormone-binding globulin [1].
  • in vivo the androgenic and the progestational activity of norgestimate were compared in two animal studies. it was found the difference in the pharmacological response in norgestimate treated rats was equivalent to the difference in the exposure of the animals to either directly administered or metabolically derived levonorgestrel [2].
  • Metabolism Norgestimate is considered to be a pro-proges tin (prodrug), because it rapidly undergoes a two-s tep m etabolic transformation to form two active products, norelgestromine (levonorgestrel 3-oxime) and levonorgestrel. Deacetylation occurs in the intestine and liver, whereas convers ion of the 3-oxime to the corresponding ketone occurs primarily in the liver. Unlike the other progestins mentioned, norgestimate and its metabolites are not bound to SHBG.
  • References [1] thomas l. lemke; david a. williams (2008). foye's principles of medicinal chemistry. lippincott williams & wilkins. pp. 1316–. isbn 978-0-7817-6879-5.
    [2] kuhnz w, beier s. comparative progestational and androgenic activity of norgestimate and levonorgestrel in the rat. contraception. 1994 mar;49(3):275-89.
    [3] https://en. wikipedia.org/wiki/norgestimate
Norgestimate Preparation Products And Raw materials
Raw materials
Preparation Products
Norgestimate Suppliers
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Norgestimate Spectrum
35189-28-7, NorgestimateRelated Search:
  • Steroids
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Hormone
  • VAGISTAT
  • Isotopically Labeled Pharmaceutical Reference Standard
  • Metabolite Reference Standard
  • 抑制剂
  • 化学试剂
  • 生物试剂
  • 日用化学品
  • 原料药
  • 原料药
  • 医药原料
  • C23H31NO3
  • 25189-28-7
  • 诺孕酯,10 MM DMSO 溶液
  • 炔诺肟酯/用于系统适用性试验/A1A
  • 炔诺肟酯/A1A
  • 炔诺肟酯|||诺孕酯
  • 诺孕酯—生物试剂
  • 诺孕
  • 诺孕酯 USP标准品
  • 诺孕 EP标准品
  • 诺孕酯系统适用性 EP标准品
  • 诺孕酯NORGESTIMATE
  • 诺孕酮杂质
  • 肟炔诺酮(诺孕脂,炔诺肟酯)
  • 炔诺圬酯
  • 诺孕酪
  • 诺孕酯
  • 炔诺肟酯
  • 炔诺肟酯溶液, 100PPM
  • 诺孕脂
  • 35189-28-7
  • Norgestimate, 10 mM in DMSO
  • Norpregnate
  • (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
  • 4-ESTREN-17α- ETHYNYL-18-HOMO-17β- OL-3-ONE(-)-ACETATE-OXIME
  • Norgestimate (1471914)
  • 35189-28-7 Norgestimate
  • NorgestimateQ: What is Norgestimate Q: What is the CAS Number of Norgestimate Q: What is the storage condition of Norgestimate Q: What are the applications of Norgestimate
  • Norgestimate USP/EP/BP
  • (8R,9S,10R,12R,14S,17S)-12-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17α)-
  • Norgestimate (Mixture of Z and E Isomers)
  • Norgestimate CRS
  • Norgestimate for system suitability CRS
  • acetic acid [(3E,8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] ester
  • NorgestimateUsp27
  • NORGESTIMATE, USP STANDARD
  • Norgestimat
  • NORGESTIMATE
  • orf10131
  • dexnorgestrelacetime
  • d-13-beta-ethyl-17-alpha-ethynyl-17-beta-acetoxygon-4-en-3-oneoxime
  • 19-dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-,3-oxime,(17-alpha)-1
  • 18,19-dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-,3-oxime,(17-alpha

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