ChemicalBook > CAS DataBase List > 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Structure
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
  • CAS No.77017-20-0
  • Chemical Name:16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
  • CBNumber:CB1894903
  • Molecular Formula:C23H28O6
  • Formula Weight:400.46482
  • MOL File:77017-20-0.mol
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Property
  • Melting point 213-215 °C(Solv: acetone (67-64-1); ligroine (8032-32-4))
  • Boiling point 576.7±50.0 °C(Predicted)
  • Density 1.31±0.1 g/cm3(Predicted)
  • storage temp. -10 to -25°C
  • solubility soluble in Acetone, Dichloromethane
  • pka 11.92±0.70(Predicted)
  • Water Solubility 38.72mg/L at 25℃
  • LogP 2.26 at 25℃
  • FDA UNII FWD7KH5JFZ
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H361-H315-H319-H411
  • Precautionary statements P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Chemical Properties,Usage,Production

  • Uses Intermediate in the preparation of antiinflammatory compounds.
  • Synthesis 2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (1 kg, 2.73 mol), acetone (50 L) and purified water (2.6 L) were added to the reaction vessel, and dissolved by stirring at room temperature; Formic acid (0.4 L, 10.60 mol) and potassium permanganate (1.2 kg, 7.59 mol) were added in that order, and the reaction was stirred at room temperature for 1 h. The reaction was quenched by the addition of saturated sodium hydrogen sulfite solution (10 L) and manganese dioxide, and some solid impurities were removed by suction filtration, and the filtrate was evaporated under reduced pressure to give a large white solid. The filter cake was washed with water to give 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate (1.01 kg, 92.2%).
    16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Suppliers
Global(51)Suppliers
  • Supplier：
    BIONNA MEDICINE CO.,LTD
  • Tel：01056380788-8515;<br/>+8618518759099
  • Email：790226113@qq.com
  • Country：China
  • ProdList：52
  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
  • ProdList：30231
  • Advantage：58
  • Supplier：
    CR Corporation Limited
  • Tel： +8613062833949
  • Email：fred.wen@crcorporation.cn
  • Country：China
  • ProdList：8647
  • Advantage：58
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Spectrum
77017-20-0, 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetateRelated Search:
  • Steroids
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • 试剂
  • 布地奈德杂质
  • 杂质对照品
  • 布地奈德杂质36
  • (16Α)-21-乙酰氧基-16,17-二羟基-孕烯-1,4,9(11)-三烯-3,20-二酮
  • 二羟基孕甾-1,4,9(11)三烯-3,20-酮-21-醋酸酯
  • 地奈德杂质M1
  • 布地奈德杂质33
  • 布地奈德杂质12
  • 21-乙酰氧基-16Α,17Α-二羟基孕甾-1,4,9(11)三烯-3,20-二酮
  • 77017-20-0
  • (16alpha)-16,17-dihydroxy-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate
  • 16α,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
  • 2-[(8S,10S,13S,14S,16R,17S)-16,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]acetate
  • Pregna-1,4,9(11)-triene-16α,17α-diol-3,20-dione 21-acetate
  • 2-((8S,10S,13S,14S,16R,17S)-16,17-Dihydroxy-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
  • "(16a)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione"
  • Desonide Impurity M1
  • 16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate
  • Budesonide Impurity 33
  • Pregna-1,4,9(11)-triene-3,20-dione,21-(acetyloxy)-16,17-dihydroxy-, (16a)- (9CI)
  • Pregna-1,4,9(11)-triene-3,20-dione, 21-(acetyloxy)-16,17-dihydroxy-, (16α)-
  • Budesonide Impurity 12
  • BNKY015-BD01
  • (16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
  • 21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione
  • Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate
  • 16-alpha,17-alpha-dihydroxy-3,20-dioxopregna- 1,4,9(11)-trien-21-yl acetate
  • 16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
  • 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate

Home

My