ChemicalBook > CAS DataBase List > trifluperidol

trifluperidol

trifluperidol Structure
trifluperidol
  • CAS No.749-13-3
  • Chemical Name:trifluperidol
  • CBNumber:CB1875676
  • Molecular Formula:C22H23F4NO2
  • Formula Weight:409.42
  • MOL File:749-13-3.mol
trifluperidol Property
  • Boiling point 515.9±50.0 °C(Predicted)
  • Density 1.2119 (estimate)
  • pka 13.87±0.20(Predicted)
  • CAS DataBase Reference 749-13-3
  • FDA UNII R8869Q7R8I
  • ATC code N05AD02
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

trifluperidol Chemical Properties,Usage,Production

  • Uses Antipsychotic.
  • Uses Trifluperidol is a powerful antipsychotic drug. It enhances the action of soporifics, narcotics, and analgesics. It also possesses anticonvulsant and antiemetic action. It is used in psychoses accompanied by motor and mental excitement, in prolonged attacks of recurrent schizophrenia, in cases accompanied by severe depression and delirium, and in alcoholic psychoses. It surpasses other neuroleptics in terms of its ability to stop minor manic excitement.
  • Definition ChEBI: Trifluperidol is an aromatic ketone.
  • brand name Triperidol (Ortho-McNeil).
  • Safety Profile Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Fand NOx. See also FLUORIDES and TRIFLUPERIDOL HYDROCHLORIDE.
  • Synthesis Trifluperidol, 4-[4-(α,α,α-trifluoro-m-tolyl)-4-hydroxypiperidino]-4′- fluorobutirophenone (6.3.3), is synthesized by reacting 1-benzyl-4-piperidone (3.1.48) with a Grignard reagent prepared from 1-trifluoromethyl-3-bromobenzene and magnesium that forms 1-benzyl-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine (6.3.1), the reduction of which with hydrogen in the presence of a palladium on carbon catalyst removes the benzyl protecting group giving 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine (6.3.2). Alkylation of the nitrogen atom of the last by ω–chloro-4-fluorobutyrophenone gives trifluperidol (6.3.3).
    Synthesis_749-13-3_1
    The 4'-chloro-4-fluorobutirophenone (6.3.4) needed for this is synthesized by the acylation of fluorobenzene using 4-chlorobutyric acid chloride.
    Synthesis_749-13-3_2
trifluperidol Preparation Products And Raw materials
Raw materials
Preparation Products
trifluperidol Suppliers
Global(19)Suppliers
  • Supplier： BOC Sciences
  • Tel： 16314854226
  • Email：info@bocsci.com
  • Country：United States
  • ProdList：9923
  • Advantage：65
  • Supplier： Wuhan Topule
  • Tel：+86-02787215551<br/>+86-19945035818
  • Email：2936752263@qq.com
  • Country：China
  • ProdList：8081
  • Advantage：58
  • Supplier：
  • Tel： 4008-099-669
  • Email：23419001name@qq.com
  • Country：CHINA
  • ProdList：73043
  • Advantage：58
trifluperidol Spectrum
749-13-3, trifluperidolRelated Search:
  • C22H23F4NO2
  • 三氟哌利多
  • 三氟哌多
  • 三氟哌啶醇
  • 三氟哌丁苯
  • 749-13-3
  • trifluperidol USP/EP/BP
  • trifluperidol
  • 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]butan-1-one
  • 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]butan-1-one
  • 4-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)butyrophenone

Home

My