Chemical Properties
| form | Liquid |
| color | Colorless to light yellow |
Racotumomab Chemical Properties,Usage,Production
Uses
Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) is an anti-idiotype monoclonal antibody (MAb). Racotumomab reacts to Neu-glycolyl (NeuGc)-containing gangliosides, sulfatides, and other antigens expressed in tumors. Racotumomab is an active anticancer agent for lung cancer[1][2][3].in vivo
Racotumomab (50 μg/dose, i.p.) together with Keyhole limpet hemocyanin (KLH) inhibits tumor growth in F3II cell (s.c.) mammary tumor mice model[2].
Racotumomab (50 μg/dose, s.c.) together with Pemetrexed (100 mg/kg) is highly effective against lung nodules in 3LL cell (s.c.) mice xenograft[3].
Racotumomab (50-200 μg/dose, s.c.) shows no significant antitumor effect in 3LL cell (s.c.) mice xenograft[3].
| Animal Model: | 3LL cell (s.c.) mice xenograft[3] |
| Dosage: | 50 μg/dose, together with Pemetrexed (100 mg/kg) |
| Administration: | Subcutaneous injection (s.c.) |
| Result: | Reduced lung nodules. |
References
[1] Vázquez AM, et al. Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides - preclinical and clinical data. Front Oncol. 2012 Oct 23;2:150. DOI:10.3389/fonc.2012.00150[2] Gajdosik Z. Racotumomab - a novel anti-idiotype monoclonal antibody vaccine for the treatment of cancer. Drugs Today (Barc). 2014 Apr;50(4):301-7. DOI:10.1358/dot.2014.50.4.2116670
[3] Segatori VI, et al. Preclinical evaluation of racotumomab, an anti-idiotype monoclonal antibody to N-glycolyl-containing gangliosides, with or without chemotherapy in a mouse model of non-small cell lung cancer. Front Oncol. 2012 Nov 8;2:160. DOI:10.3389/fonc.2012.00160
[4] Truong CS, et al. Oncolytic Vaccinia Virus in Lung Cancer Vaccines. Vaccines (Basel). 2022 Feb 4;10(2):240. DOI:10.3390/vaccines10020240
Racotumomab Suppliers
Global(23)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | 32430 | 58 | ||
| 027-87531629 | Proteintech-CN@ptglab.com | 6276 | 58 | ||
| 027-87008169 17762441161 | info@atagenix.com | 9997 | 58 | ||
| 18916372613 | yanzihan@shyuanye.com | 87240 | 60 | ||
| +44 (0)1223 859 353 | info@biorbyt.com | 6478 | 58 | ||
| 13370042665 18916960931 | 3623107365@qq.com | 17234 | 58 | ||
| 18007167883 18007167883 | Service@mabnus.com | 921 | 58 | ||
| 027-027-16602739303 16602739303 | 673003916@qq.com | 4951 | 58 | ||
| 4008200310 15002144251 | marketing@tsbiochem.com | 24951 | 58 | ||
| 400-821-026 | Sales@sangon.com | 6860 | 58 |