Lorvotuzumab Mertansine
- Product NameLorvotuzumab Mertansine
- CAS1008106-64-6
- CBNumberCB18080733
- MW0
- MOL FileMol file
Chemical Properties
Lorvotuzumab Mertansine Chemical Properties,Usage,Production
Uses
Lorvotuzumab mertansine is an ADC consisting of a humanized N901 monoclonal antibody against CD56 bound to maytansinoid DM1 via a stable disulfide linker. Lorvotuzumab mertansine has antitumor activity[1].in vivo
Lorvotuzumab mertansine (3-51 mg/kg, i.v., once) has potent anti-tumour activity in CB.17 SCID mice with SW2 SCLC xenograft tumor[1].
| Animal Model: | SW2 SCLC xenograft tumor CB.17 SCID mice |
| Dosage: | 3、17 and 51 mg/kg |
| Administration: | i.v., once |
| Result: | Showed high anti-tumor activity at a dose of 17 mg/kg with half of the animals being tumor free and complete tumor regression at a dose of 51 mg/kg. |
References
[1] Kathleen R Whiteman, et al. Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models. MAbs. 2014 Mar-Apr;6(2):556-66. DOI:10.4161/mabs.27756Lorvotuzumab Mertansine Suppliers
Global(18)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +1-631-485-4226 | inquiry@bocsci.com | 19934 | 58 | ||
| 18317699790 18317699790 | l202008112023@163.com | 7733 | 58 | ||
| 33175446423 | support@antibodysystem.com | 6737 | 58 | ||
| 51288865780 | sales@biosynth.com | 6031 | 58 | ||
| 400-668-6834 | info@selleck.cn | 6061 | 58 | ||
| 9785721070 | info@cellsciences.com | 6307 | 58 | ||
| 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | 7353 | 58 | ||
| 027-65317797 15926423062 | 422450190@qq.com | 10300 | 58 | ||
| 15111215862 18229892877 | 3062105966@qq.com | 5580 | 58 | ||
| 4000880777 17585207275 | guojing@bioleaper.com | 5615 | 58 |