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Azido-PEG8-hydrazide

Azido-PEG8-hydrazide Structure
Azido-PEG8-hydrazide
  • CAS No.2353410-11-2
  • Chemical Name:Azido-PEG8-hydrazide
  • CBNumber:CB18054666
  • Molecular Formula:C19H39N5O9
  • Formula Weight:481.55
  • MOL File:2353410-11-2.mol
Azido-PEG8-hydrazide Property
  • solubility Soluble in Water
  • form Solid
  • color White to off-white
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Azido-PEG8-hydrazide Chemical Properties,Usage,Production

  • Description Azido-PEG8-hydrazide HCl salt is a wter soluble PEG linker containing an azide group and a hydrazide moiety. The hydrophilic PEG spacer increases solubility of a compound in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond.
  • Uses Azido-PEG8-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG8-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG8-hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG8-hydrazide Suppliers
Global(19)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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    Alfa Chemistry
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  • Supplier：
    Aladdin Scientific
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  • Email：tp@aladdinsci.com
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Azido-PEG8-hydrazide Spectrum
2353410-11-2, Azido-PEG8-hydrazideRelated Search:
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  • 2353410-11-2
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