ChemicalBook > CAS DataBase List > 5-Amino-2-nitrobenzoic acid

5-Amino-2-nitrobenzoic acid

CAS No.13280-60-9
Chemical Name:5-Amino-2-nitrobenzoic acid
CBNumber:CB1738500
Molecular Formula:C7H6N2O4
Formula Weight:182.13
MOL File:13280-60-9.mol

5-Amino-2-nitrobenzoic acid Property

Melting point 236-238 °C (lit.)
Boiling point 481.3±35.0 °C(Predicted)
Density 1.568±0.06 g/cm3(Predicted)
vapor pressure 0-0Pa at 20-50℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO, Methanol
pka 2.28±0.25(Predicted)
form Solid
color Yellow-Brown
Water Solubility Insoluble
BRN 2107512
InChIKey KZZWQCKYLNIOBT-UHFFFAOYSA-N
LogP -1.48 at pH7
Surface tension 70.53mN/m at 1g/L and 20℃
CAS DataBase Reference 13280-60-9(CAS DataBase Reference)
FDA UNII XF6GS4UH6B
UNSPSC Code 12352106
NACRES NA.22

Safety

Hazard Codes :Xn
Risk Statements :36/37/38-22-20/21/22
Safety Statements :26-36/37/39-37/39-36
WGK Germany :3
HS Code :29224999

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H335-H315-H319
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

5-Amino-2-nitrobenzoic acid Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: 564613
Product name : 5-Amino-2-nitrobenzoic acid
Purity: 97%
Packaging: 5G
Price: ₹6246.03
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A1048
Product name : 5-Amino-2-nitrobenzoic Acid (Purified) [for γ-GT]
Purity:
Packaging: 100MG
Price: ₹6900
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A0897
Product name : 5-Amino-2-nitrobenzoic Acid
Purity:
Packaging: 5G
Price: ₹5900
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A0897
Product name : 5-Amino-2-nitrobenzoic Acid
Purity:
Packaging: 25G
Price: ₹15300
Updated: 2022/05/26
Buy: Buy

5-Amino-2-nitrobenzoic acid Chemical Properties,Usage,Production

Description 5-Amino-2-nitrobenzoic acid is a reagent used in preparation of polymer-bound diazonium salts and insulin receptor tyrosine kinase activator. It is also used in 2-component dendritic chain reactions and activation of hydrophobic dendrimers.
Chemical Properties 5-Amino-2-nitrobenzoic acid appears as a yellow powder or crystal. Its crystal structure is: the 5-amino-2-nitrobenzoic acid crystallizes in the monoclinic P21/c space group with a = 3.898(2)?, b = 13.531(3)?, c = 14.301(3) ?, and β = 90.83(3)?. The adjacent molecules form a cyclic dimmer by intermolecular hydrogen bonds of type O H···O with their carboxyl groups. In the crystal structure NH2 group forms a threecenter hydrogen bond with oxygen atoms of NO2 group.
Uses 5-Amino-2-nitrobenzoic acid can be used as a standard for the determination of γ-GT activity using 5-amino-2-nitrobenzoic acid as a standard. 5-Amino-2-nitrobenzoic acid (ANB) can also be used for spectroscopic studies by determining the FTIR and FT-Raman spectra of ANB in the 400-4000 cm-1 range and calculating the theoretically constructed spectra in good agreement with the experimental spectra.
Uses Reactant for:
- Two-component dendritic chain reactions
- Enzymic activation of hydrophobic self-immolative dendrimers
- Preparation of insulin receptor tyrosine kinase activator
- Preparation of polymer-bound diazonium salts using Merrifield resin-bound piperazine
Application 5-Amino-2-nitrobenzoic acid is a drug that has been shown to inhibit the activity of proteases. It has been used to detect the presence of protease activity in urine samples, as well as to study the inhibition of protease activity by other drugs. It is an inhibitor of chymotrypsin, trypsin, and elastase. This drug has been shown to be effective in inhibiting these enzymes at low concentrations, with a detection sensitivity of approximately 0.1 μM. It inhibits the growth of bacteria by binding to them and preventing protein synthesis. The compound also inhibits the enzyme dihydrolipoamide dehydrogenase in mitochondria, which is required for cellular respiration and energy production.
reaction suitability reaction type: solution phase peptide synthesis
Purification Methods Crystallise the acid from water. [Beilstein 14 III 1021.]