Synthesis
GENERAL PROCEDURE: Methyl indole-3-carboxylate (5 mmol) was slowly added to hydrazine hydrate (80%, 3 mL) at room temperature. Subsequently, the reaction mixture was subjected to continuous microwave irradiation at 300 W for 5-8 min. The reaction process was monitored by thin layer chromatography (TLC). Once the reaction was complete, the mixture was cooled sufficiently to room temperature to afford the intermediate indole-3-carbohydrazide in 83-98% yield.
References
[1] Journal of Chemical Research, 2015, vol. 39, # 5, p. 296 - 299
[2] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 22 - 32
[3] Chemistry of Heterocyclic Compounds, 1982, vol. 18, # 3, p. 258 - 261
[4] Pharmazie, 2017, vol. 72, # 12, p. 707 - 713
[5] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 10, p. 1270 - 1275
