ChemicalBook > CAS DataBase List > Synephrine hydrochloride

Synephrine hydrochloride

Synephrine hydrochloride Structure
Synephrine hydrochloride
  • CAS No.5985-28-4
  • Chemical Name:Synephrine hydrochloride
  • CBNumber:CB1690109
  • Molecular Formula:C9H14ClNO2
  • Formula Weight:203.67
  • MOL File:5985-28-4.mol
Synephrine hydrochloride Property
  • Melting point 147-150°C
  • storage temp. Refrigerator
  • solubility Methanol (Slightly), Water (Slightly)
  • form Solid
  • color Off-White to Pale Beige
  • InChI InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
  • InChIKey COTCEGYSNTWJQV-UHFFFAOYSA-N
  • SMILES C1(=CC=C(O)C=C1)C(O)CNC.Cl
  • LogP -0.030 (est)
  • CAS DataBase Reference 5985-28-4(CAS DataBase Reference)
  • FDA UNII EN5D1IH09S
Safety
  • HS Code  :2922498590
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H335-H319
  • Precautionary statements P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Synephrine hydrochloride Chemical Properties,Usage,Production

  • Description (±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.
  • Chemical Properties Pale Beige Solid
  • Uses A α-adrenergic receptor agonist, vasoconstrictor.
Synephrine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Synephrine hydrochloride Suppliers
Global(366)Suppliers
  • Supplier：
    Chengdu ChenLv Herb Co.,Ltd
  • Tel：+86-13608205856;<br/>+undefined13608205856
  • Email：maryextract@126.com
  • Country：China
  • ProdList：127
  • Advantage：58
  • Supplier：
    BINBO BIOLOGICAL CO.,LTD
  • Tel： +8618629063126
  • Email：info@binbobiological.com
  • Country：China
  • ProdList：452
  • Advantage：58
Synephrine hydrochloride Spectrum
5985-28-4, Synephrine hydrochlorideRelated Search:
  • 5985-28-4
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors
  • Amines
  • 大化工产品
  • 中药标准品，对照品
  • 主打产品
  • 化学原料
  • 抑制剂
  • 药靶配体
  • 精细化工原料
  • 原料
  • 化工原料
  • 植物单体
  • 化学试剂
  • 原料药
  • 辛弗林盐酸盐
  • 合成材料中间体
  • 添加剂1
  • 标准品 -中药标准品
  • 对照品
  • 中药对照品
  • 医药类
  • 植物化学药
  • 医药原料
  • 小分子抑制剂，天然产物
  • 医药原料药
  • 医药保健
  • 香精香料
  • 标准品
  • 植物提取物
  • 保健品添加剂
  • 植提标准品
  • 盐
  • C9H14NO2Cl
  • 59485-28-4
  • 5984-28-4
  • 85-28-4
  • 5983-28-4
  • 8985-28-4
  • 227-804-6
  • 辛弗林盐酸盐,10 MM DMSO 溶液
  • 辛氟林酸盐
  • 辛弗林盐酸
  • 盐酸肾上腺素杂质G
  • 盐酸辛弗林, 是衍生自柑橘类植物的 Α-ADRENERGIC 和 -ADRENERGIC 激动剂,与麻黄和麻黄碱生物碱具有拟交感神经和结构相似性
  • 辛弗林盐酸盐/盐酸辛弗林/新福林盐酸盐
  • 辛弗林盐酸盐/盐酸辛弗林
  • 辛弗林盐酸盐 98%MIN
  • 氯化[2-羟基-2-(4-羟苯基)乙基]-甲基铵
  • 对-甲基氨基乙醇苯酚盐酸盐
  • 4-[1-羟基-2-(甲基氨基)乙基]苯酚2,3-二羟基琥珀酸盐(盐)
  • 4-[1-羟基-2-(甲氨基)乙基]苯酚盐酸盐
  • 辛弗林盐酸盐(标准品)
  • 辛弗林盐酸盐
  • 盐酸盐辛佛宁
  • 氯化[2-羟基-2-(4-羟苯基)乙基]-甲基-铵

Home

My