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Phenyl dichlorophosphate

CAS No.770-12-7
Chemical Name:Phenyl dichlorophosphate
CBNumber:CB1669062
Molecular Formula:C6H5Cl2O2P
Formula Weight:210.98
MOL File:770-12-7.mol

Phenyl dichlorophosphate Property

Melting point -1 °C
Boiling point 241-243 °C (lit.)
Density 1.412 g/mL at 25 °C (lit.)
vapor pressure 2.33Pa at 25℃
refractive index n20/D 1.523(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility soluble in Chloroform
form Liquid
color Clear colorless to very slightly brown
Water Solubility Decomposes
Sensitive Moisture Sensitive
Merck 14,7282
BRN 511863
Stability Moisture Sensitive
InChIKey TXFOLHZMICYNRM-UHFFFAOYSA-N
CAS DataBase Reference 770-12-7(CAS DataBase Reference)
FDA UNII AE85WW9S5Z
NIST Chemistry Reference Phosphorodichloridic acid, phenyl ester(770-12-7)
EPA Substance Registry System Phosphorodichloridic acid, phenyl ester (770-12-7)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :C
Risk Statements :34-37
Safety Statements :26-36/37/39-45
RIDADR :UN 3265 8/PG 2
WGK Germany :3
RTECS :TD4393000
F :10
TSCA :Yes
HazardClass :8
PackingGroup :II
HS Code :29209085

NFPA 704:

	0
3		0
	W

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H314
Precautionary statements P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

Phenyl dichlorophosphate Price More Price(9)

Brand: Sigma-Aldrich(India)
Product number: P22389
Product name : Phenyl dichlorophosphate
Purity: ≥95%
Packaging: 25G
Price: ₹4416.6
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: P22389
Product name : Phenyl dichlorophosphate
Purity: ≥95%
Packaging: 100G
Price: ₹9850.75
Updated: 2022/06/14
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Brand: ALFA India
Product number: ALF-A10479-36
Product name : Phenyl phosphorodichloridate, 97%
Purity:
Packaging: 500g
Price: ₹20500
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-A10479-22
Product name : Phenyl phosphorodichloridate, 97%
Purity:
Packaging: 100g
Price: ₹6889
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-A10479-14
Product name : Phenyl phosphorodichloridate, 97%
Purity:
Packaging: 25g
Price: ₹2839
Updated: 2022/05/26
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Phenyl dichlorophosphate Chemical Properties,Usage,Production

Chemical Properties clear colourless to very slightly brown liquid
Uses Reagent for the preparation of phosphate diesters.
Uses Reagent for preparation of phosphate diesters. Phenyl dichlorophosphate is used in the preparation of symmetrical phosphate diesters. It is used as a phosphorylating agent for alcohols and amines. It is also involved in the preparation of phenylphosphoro di-(1-imidazolidate) and 2-phenyl-bis-triazoloylphosphate, which is used in peptide synthesis. It plays a vital role in the Pfitzner-Moffatt oxidation which involves oxidation of alcohols to the corresponding aldehydes and ketones. Furthermore, it is utilized in Beckmann rearrangement for the preparation of N-phenylacetamide from acetophenone oxime.
Uses In organic synthesis for preparation of lactams, phosphate diesters and for oxidation reactions.
Preparation The preparation of Phenyl dichlorophosphate is as follows:160 g (1 mol) of phosphorus oxychloride and 1 g of titanium tetrachloride were respectively added to a four-necked flask to carry out the reaction, and the temperature was raised to 70-80° C., and phenol (94 g, 1 mol) was slowly added dropwise. The phenol addition time was about 2- 3 hours,After completion of the dropwise addition, the reaction is maintained at 80-90° C. for 3-5 hours. After no hydrogen chloride is evolved, the reaction is completed. After the reaction, the phosphorus oxychloride is distilled under reduced pressure, the vacuum degree is 30-100 KPa, and the distillation temperature is 30-100° C. Distillation under reduced pressure to obtain the intermediate of the mixture, a mono-substituted and di-substituted mixture of phosphorus oxychloride, the ratio of the mixture is 5:5, gas phase analysis to obtain the intermediate of the mixture, the yield of the intermediate is 95%, phosphorus oxychloride The recovery rate is 95% (calculated as phosphorus oxychloride).
General Description A liquid. May severely irritate skin, eyes and mucous membranes.
Air & Water Reactions About the same density as water and moderately soluble in water.
Reactivity Profile An hologenated organophosphate. Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Hazard May cause severe skin, eye, and mucous membrane irritation; Reacts violently with water; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion; Highly toxic by skin absorption; Dermal LD50 (guinea pig) = 14-400 mg/kg.
Health Hazard TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.