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α-Pseudouridine

α-Pseudouridine Structure
α-Pseudouridine
  • CAS No.10017-66-0
  • Chemical Name:α-Pseudouridine
  • CBNumber:CB1504121
  • Molecular Formula:C9H12N2O6
  • Formula Weight:244.2
  • MOL File:10017-66-0.mol
α-Pseudouridine Property
  • InChI InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7-/s3
  • InChIKey PTJWIQPHWPFNBW-DVJSAIJENA-N
  • SMILES C1(=O)NC=C([C@@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C(=O)N1 |&1:5,6,8,10,r|
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

α-Pseudouridine Chemical Properties,Usage,Production

  • Description Alpha-pseudouridine is an unusual nucleoside with a "glycosidic" carbon-carbon bond.
  • Uses Alpha-Pseudouridine is an isomer of Pseudouridine. It is a by-product of the chemical synthesis of beta-pseudouridine, is eliminated in EnginZyme’s enzymatic synthesis process. Pseudouridine is a fundamental component of RNA, found in all classes and species except the messenger (mRNA) variety. It most abundant RNA modification, found in all three phylogenic domains of life. When used in place of uridine in artificial mRNA, pseudouridine has proven to be critical to the success of mRNA vaccines (such as those for Covid-19) and future mRNA-based treatments.
  • References [1] BARáT V, CHEN A, LIM Y H. An improved stereodivergent and practical synthesis of α- and β-pseudouridines?[J]. Reaction Chemistry & Engineering, 2022, 4: 798-803. DOI:10.1039/D2RE00381C.
    [2] HAIQI XU. Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome[J]. Nature Methods, 2024, 21 11: 2024-2033. DOI:10.1038/s41592-024-02439-8.
    [3] MARTIN HENGESBACH. Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET.[J]. RNA, 2010, 16 3: 610-620. DOI:10.1261/rna.1832510.
α-Pseudouridine Preparation Products And Raw materials
Raw materials
Preparation Products
α-Pseudouridine Suppliers
Global(19)Suppliers
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  • Supplier： Zhejiang Huida Biotech Co., LTD
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α-Pseudouridine Spectrum
  • Pharmaceutical
  • 化工中间体
  • 化学试剂
  • 假脲苷
  • Α-假尿苷
  • 10017-66-0
  • 5-α-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
  • α-Pseudouridine
  • α-Pseudouricdine
  • Pseudouridine B
  • 5-(α-D-Ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
  • 5-(β-D-Ribofuranosyl)uracil from wheat bran
  • ALPHA-Pseudouridine
  • PSEUDOURIDINE NATURAL B ISOMER*FROM WHEAT BRAN

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