Description
Isoscopolamine is an antiasthmatic drug, which has the effect of relaxing smooth muscle and antihistamine. It can be used clinically in patients with chronic bronchitis and bronchial asthma.
Chemical Properties
Yellow needle-like crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Dengzhanhua, Rhododendron.
Uses
Isoscopolamine has anti-inflammatory, antioxidant, improving myocardial ischemia, anti-arrhythmic effects.
Definition
ChEBI: Isoscopoletin is a hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone. It has a role as a plant metabolite. It is a hydroxycoumarin and an aromatic ether. It is functionally related to an esculetin.
Biological Activity
Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active ingredient in Artemisia argyi. It has a significant inhibitory effect on cell proliferation with IC50 values of 4.0 μM and 1.6 μM against human CCRF-CEM leukemia cells and drug-resistant subline CEM/ADR5000, respectively. It (6-Hydroxy-7-methoxycoumarin) has the activity of inhibiting HBV replication.
