D-Sedoheptulose-7-phosphate (barium salt)

Description

D-Sedoheptulose-7-phosphate is an intermediate in the pentose phosphate pathway.^1,2 In this pathway, transaldolase catalyzes the transfer of a three carbon dihydroxyacetone moiety from D-sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to generate D-fructose-6-phosphate. D-Sedoheptulose-7-phosphate is also an intermediate in carbon fixation in photosynthetic organisms, as well as in the biosynthesis of lipopolysaccharide, amino acids, secondary metabolites, and antibiotics.³

Uses

D-Sedoheptulose-7-phosphate barium is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose-7-phosphate barium can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds [1].

IC 50

Human Endogenous Metabolite

References

1. Gumaa, K.A., and McLean, P. The pentose phosphate pathway of glucose metabolism: Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells Biochem. J. 115(5),1009-1029(1969).
2. Patra, K.C., and Hay, N. The pentose phosphate pathway and cancer Trends Biochem. Sci. 39(8),347-354(2014).
3. Wolosiuk, R.A., Ballicora, M.A., and Hagelin, K. The reductive pentose phosphate cycle for photosynthetic CO2 assimilation: Enzyme modulation FASEB J. 7(8),622-637(1993).