Chemical Properties
Clear yellow liquid
Uses
4-Pentyn-1-ol is an alkyne alcohol that is used as an initiator in ring-opening polymerization reactions. 4-Pentyn-1-ol is capable of undergoing cyclosisomerization, and is also used as a reactant in the synthesis of (+)-Serinolamide A, a cannabinoid CB1 receptor agonist.
Application
4-Pentyn-1-ol was used in preparation of 3-pent-4-ynyloxy phthalonitrile. It was also used as starting reagent in stereoselective total synthesis of antimicrobial marine metabolites, ieodomycin A and B.
General Description
Mechanism of (THF)W(CO)
5-promoted endo- and exo-cycloisomerization of 4-pentyn-1-ol was studied.
Synthesis
4-Pentyn-1-ol has been prepared from 4-penten-1-ol by bromination followed by dehydrobromination with alkali.
