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1-Dodecanol

CAS No.112-53-8
Chemical Name:1-Dodecanol
CBNumber:CB1334632
Molecular Formula:C12H26O
Formula Weight:186.33
MOL File:112-53-8.mol

1-Dodecanol Property

Melting point 22-26 °C(lit.)
Boiling point 260-262 °C(lit.)
Density 0.833 g/mL at 25 °C(lit.)
vapor density 7.4 (vs air)
vapor pressure 0.1 mm Hg ( 20 °C)
FEMA 2617 | LAURYL ALCOHOL
refractive index n20/D 1.442(lit.)
Flash point >230 °F
storage temp. Store below +30°C.
solubility water: slightly soluble1g/L at 23°C
form Liquid
pka 15.20±0.10(Predicted)
color APHA: ≤10
Odor Typical fatty alcohol odor; sweet.
explosive limit 4%
Odor Type waxy
biological source synthetic
Viscosity 11.251mm2/s
Water Solubility insoluble
Merck 14,3405
JECFA Number 109
BRN 1738860
Dielectric constant 6.5（24℃）
InChIKey LQZZUXJYWNFBMV-UHFFFAOYSA-N
LogP 5.4 at 23℃
Substances Added to Food (formerly EAFUS) LAURYL ALCOHOL
FDA 21 CFR 175.105; 175.300; 177.1200
CAS DataBase Reference 112-53-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 178A96NLP2
NIST Chemistry Reference 1-Dodecanol(112-53-8)
EPA Substance Registry System 1-Dodecanol (112-53-8)
UNSPSC Code 85151701
NACRES NA.24

Safety

Hazard Codes :Xi,N
Risk Statements :38-50-50/53-36/38-36/37/38
Safety Statements :61-37/39-29-26-60-36
RIDADR :UN 3077 9/PG 3
WGK Germany :1
RTECS :JR5775000
Autoignition Temperature :500 °F
TSCA :Yes
HazardClass :9
PackingGroup :III
HS Code :29051700
Hazardous Substances Data :112-53-8(Hazardous Substances Data)
Toxicity :LD50 orally in Rabbit: > 5000 mg/kg

NFPA 704:

	1
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319-H410
Precautionary statements P264-P273-P280-P305+P351+P338-P337+P313-P391

1-Dodecanol Price More Price(25)

Brand: Sigma-Aldrich(India)
Product number: W261718
Product name : Lauryl alcohol
Purity: ≥98%, FG
Packaging: 1SAMPLE-K
Price: ₹5141.88
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: W261718
Product name : Lauryl alcohol
Purity: ≥98%, FG
Packaging: 1KG
Price: ₹6971.3
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: W261718
Product name : Lauryl alcohol
Purity: ≥98%, FG
Packaging: 4KG
Price: ₹11236.35
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: W261718
Product name : Lauryl alcohol
Purity: ≥98%, FG
Packaging: 8KG
Price: ₹22559.3
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: W261718
Product name : Lauryl alcohol
Purity: ≥98%, FG
Packaging: 20KG
Price: ₹36101.38
Updated: 2022/06/14
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1-Dodecanol Chemical Properties,Usage,Production

Physical properties 1-Dodecanol is a white low melting crystalline solid that has a melting point of 24°C.The air odor threshold for dodecyl alcohol (isomer not specified) is reported to be 7.1 ppb.
Chemical Properties Lauryl alcohol has a characteristic fatty odor; unpleasant at high concentrations, but delicate and floral on dilution. 1-Dodecanol is a saturated 12-carbon fatty alcohol obtained from coconut oil fatty acids. It has a fatty, waxy flavor and is used in detergents, lubricating oils, and pharmaceuticals.
Occurrence Reported found in the oil of Mexican lime and in the oil from flowers of Furcraea gigantean. Also reported found in apple, banana, sour cherry, citrus peel oils, melon, pineapple, potato, thymus, cheeses, butter, milk powder, chicken and beef fat, cooked pork, beer, whiskies, white wine, peanuts, beans, mushrooms, mango, coriander seed and leaf, rice, Bourbon vanilla, endive, crab, clam, Cape gooseberry, pawpaw and maté.
Uses 1-Dodecanol is used in chemical formulations for a variety of purposes, including as an emulsion stabilizer, a skin-conditioning emollient, and a viscosity-increasing agent.
Uses 1-Dodecanol is used as a cosmetic, textile auxiliaries, synthetic oil, emulsifiers and flotation agent of raw materials, a detergent raw material, a foaming agent of the toothpaste.
Production Methods 1-Dodecanol is produced commercially by the oxo process and from ethylene by the Ziegler process, which involves oxidation of trialkylaluminum compounds. It can also be produced by sodium reduction or high-pressure hydrogenation of esters of naturally occurring lauric acid.
Preparation Commercially 1-Dodecanol may be prepared by hydrogenation of lauric acid; normally employed as a replacement for the corresponding aldehyde.
Definition ChEBI: 1-Dodecanol is a fatty alcohol that is dodecane in which a hydrogen from one of the methyl groups is replaced by a hydroxy group. It is registered for use in apple and pear orchards as a Lepidopteran pheromone/sex attractant, used to disrupt the mating behaviour of certa n moths whose larvae destroy crops.
Aroma threshold values Detection: 73 to 820 ppb
Synthesis Reference(s) Journal of the American Chemical Society, 108, p. 6036, 1986 DOI: 10.1021/ja00279a061
Tetrahedron Letters, 37, p. 3623, 1996 DOI: 10.1016/0040-4039(96)00652-1
General Description Colorless thick liquid with a sweet odor. Floats on water. Freezing point is 75°F.
Reactivity Profile Dodecyl alcohol is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Health Hazard Liquid will cause burning of the eyes and may irritate skin.
Flammability and Explosibility Non flammable
Safety Profile Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. A severe human skin irritant. Questionable carcinogen with experimental tumorigenic data. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use dry chemical, CO2. When heated to decomposition it emits acrid smoke and irritating fumes
Carcinogenicity 1-Dodecanol showed weak tumor-promoting activity when applied three times a week for 60 weeks to the skin of mice that had previously received an initiating dose of dimethylbenz[a]anthracene. Papillomas developed in 2 of 30 mice after 39 and 49 weeks of treatment.
Purification Methods Crystallise dodecanol from aqueous EtOH, and distil it through a spinning-band column under vacuum. [Ford & Marvel Org Synth 10 62 1930, Beilstein 1 IV 1844.]