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ANGIOTENSIN III, HUMAN

ANGIOTENSIN III, HUMAN Structure
ANGIOTENSIN III, HUMAN
  • CAS No.13602-53-4
  • Chemical Name:ANGIOTENSIN III, HUMAN
  • CBNumber:CB1334627
  • Molecular Formula:C46H66N12O9
  • Formula Weight:931.09
  • MOL File:13602-53-4.mol
ANGIOTENSIN III, HUMAN Property
  • Density 1.39±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility H2O: 1.0 mg/mL, clear, colorless
  • form Lyophilized.
  • pka 3.56±0.10(Predicted)
  • color White to off-white
  • FDA UNII XH7F04LXTF
Safety
  • WGK Germany  :3
  • F  :10
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

ANGIOTENSIN III, HUMAN Chemical Properties,Usage,Production

  • Description Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT1) and AT2 receptors, with a 30-fold higher affinity for AT2 compared with AT1 in HEK293 cells. Ang III is the preferred agonist for renal AT2 receptors, which are responsible for sodium excretion into the urine. Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity in vivo. In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure.
  • Uses Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.
  • Definition ChEBI: Angiotensin III is a peptide.
  • in vivo

    Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (UNaV), fractional excretion of sodium (FENa), and fractional excretion of lithium (FELi) in SD rat[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats[3].

  • IC 50 AT2 Receptor
  • References [1] Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. DOI:10.1042/CS20110036
    [2] Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95. DOI:10.1161/HYPERTENSIONAHA.112.191403
    [3] Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48. DOI:10.1042/CS20130396
ANGIOTENSIN III, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
ANGIOTENSIN III, HUMAN Suppliers
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ANGIOTENSIN III, HUMAN Spectrum
13602-53-4, ANGIOTENSIN III, HUMANRelated Search:
  • peptide
  • Angiotensin
  • Cardiovascular
  • 目录肽
  • 目录多肽
  • 抑制剂
  • 药靶配体
  • 多肽
  • 血管紧张素III,ANGIOTENSIN III, HUMAN, MOUSE(3TFA)
  • 血管紧张素 III,人,小鼠(醋酸盐)
  • 血管紧张素 ANGIOTENSIN III, HUMAN
  • PERFEMIKER]ANGIOTENSIN III, HUMAN, MOUSE,98%
  • 血管紧张素III
  • 13602-53-4
  • Angiotensin III - 5 mg
  • Angiotensin III, human, mouse（Acetate）
  • Angiotensin Receptor,Inhibitor,Angiotensin III, human, mouse,inhibit
  • ANGIOTENSIN III, HUMAN USP/EP/BP
  • Human angiotensin III/Angiotensin III(mouse)
  • 2-8-Angiotensin II, 5-L-isoleucine-
  • Angiotensin III, human, mouse(3TFA)
  • Angiotensin III H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
  • angiotensin III, 5-Ile-
  • RVYIHPF
  • ANGIOTENSIN II HEPTAPEPTIDE
  • ANGIOTENSIN III (HUMAN, MOUSE)
  • ANGIOTENSIN III (HUMAN) 2ACOH 4H2O
  • ANGIOTENSIN III, HUMAN
  • ANGIOTENSIN III
  • ANGIOTENSIN III ACETATE SALT
  • DES-ASP-1-ANGIOTENSIN II ACETATE SALT
  • [DES-ASP1]-ANGIOTENSIN II
  • H-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH
  • ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH CH3COOH 4H2O
  • ARG-VAL-TYR-ILE-HIS-PRO-PHE 2ACOH 4H2O
  • ARG-VAL-TYR-ILE-HIS-PRO-PHE

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