Big ET-1 (22-38) (human)

Big Endothelin-1 (22-38), human (3 nM/kg; intra-arterial injection; single dose) produces a significant rise in left ventricular systolic pressure (LVSP) in anesthetized rabbits, and is enhanced by cyclooxygenase inhibitor Indomethacin (HY-14397) (5 mg/kg i.v.) significantly^[3].
Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits^[3].