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Ethopabate

CAS No.59-06-3
Chemical Name:Ethopabate
CBNumber:CB1307306
Molecular Formula:C12H15NO4
Formula Weight:237.25
MOL File:59-06-3.mol

Ethopabate Property

Melting point 148-151 °C
Boiling point 426.1±35.0 °C(Predicted)
Density 1.180±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO: 50 mg/mL (210.75 mM)
form A solid
pka 14.12±0.70(Predicted)
color White to off-white
Merck 13,3781
InChI InChI=1S/C12H15NO4/c1-4-17-11-7-9(13-8(2)14)5-6-10(11)12(15)16-3/h5-7H,4H2,1-3H3,(H,13,14)
InChIKey GOVWOKSKFSBNGD-UHFFFAOYSA-N
SMILES C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OCC
CAS DataBase Reference 59-06-3(CAS DataBase Reference)
FDA 21 CFR 556.260
FDA UNII F4X3L6068O
EPA Substance Registry System Ethopabate (59-06-3)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn
Risk Statements :22
WGK Germany :3
HS Code :2924296000

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H319
Precautionary statements P264-P270-P280-P301+P312-P305+P351+P338-P337+P313

Ethopabate Chemical Properties,Usage,Production

Description Ethopabate is a veterinary drug belonging to the class of antibiotics which contains an arylamide with a phenyl ring, a monocyclic aromatic hydrocarbon, and is a very safe drug used for the prophylaxis and treatment of coccidiosis in chickens. It has anticoccidial activity, especially against the intestinal form, and lacks activity against E. tenella of the cecum worm. The drug is a competitor of PABA, which is absorbed by the parasite and interferes with folate synthesis. It has good activity against E. acervulina and some strains of E. maxima and E. brunette. It is used only in combination with amprolium, first at a concentration of 4 ppm and later at a concentration of 40 ppm.This drug reaches peak activity on day 4 of the cycle.
Chemical Properties White to Off-White Solid
Uses A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens.
Uses antidepressant
Definition ChEBI: Ethopabate is an amidobenzoic acid.
Clinical Use Ethopabate is only a narrow anticoccidial spectrum drug against Eimeria acervulina. It has no or only slight activity against E. maxima, E. necatrix, E. tenella or E. brunetti. Today, ethopabate is applied only in combination with amprolium and sulfonamide.
Molecular Interactions Ethopabate is a 2-substituted PABA derivative (=4-acetamido-2-ethoxybenzoic acid methylester) and functions as a prodrug. Its activity becomes potentiated by pyrimethamine and antagonised by the simultaneous administration of PABA. Thus, the mode of action of ethopabate is similar to that of sulfonamides or sulfones.